Ann Lab Med.  2020 Jan;40(1):76-79. 10.3343/alm.2020.40.1.76.

First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient With T-cell Acute Lymphoblastic Leukemia

• Seol CA
• Cho YU
• Jang S
• Park CJ
• Lee JH
• Seo EJ

• KMID: 2457498
• DOI: http://doi.org/10.3343/alm.2020.40.1.76

Abstract

No abstract available.

MeSH Terms

Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Receptors, Antigen, T-Cell*
T-Lymphocytes*
Receptors, Antigen, T-Cell

Figure

• 

  Fig. 1 BM examination, karyotyping, and FISH analysis at diagnosis. (A) Lymphoblasts on the BM aspirate smear (Wright-Giemsa, ×1,000). (B) BM karyogram. (C, D) Metaphase and interphase FISH analyses with TRA/D Dual Color Break Apart Rearrangement Probe for 14q11.2 (5′TRA/D: SpectrumRed, 3′TRA/D: SpectrumGreen). Abbreviations: BM, Bone marrow; FISH, fluorescence in situ hybridization; inv, inversion; der, derivative chromosome; TRA/D, T-cell receptor alpha/delta.

• 

  Fig. 2 BM examination, karyotyping, and FISH analysis at follow-up. (A) Eosinophils (Wright-Giemsa, ×1,000) and (B) focal fibrosis (HE, ×400). (C) BM karyogram. (D) Metaphase and interphase FISH analyses with JAK2 Break Apart FISH Probe for 9p24.1 (5′JAK2: Red, 3′JAK2: Green). (E) Interphase FISH analysis with RP11-162F6 (LMO2) for 11p13 (Aqua) and TRA/D Dual Color Break Apart Rearrangement Probe for 14q11.2 (5′TRA/D: SpectrumRed, 3′TRA/D: SpectrumGreen). Abbreviations: BM, Bone marrow; HE, hematoxylin and eosin; FISH, fluorescence in situ hybridization; der, derivative chromosome; TRA/D, T-cell receptor alpha/delta.

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