J Gynecol Oncol.  2019 Mar;30(2):e18. 10.3802/jgo.2019.30.e18.

Major clinical research advances in gynecologic cancer in 2018

• Kim M
• Suh DH
• Lee KH
• Eom KY
• Toftdahl N
• Mirza MR
• Kim JW

• KMID: 2457131
• DOI: http://doi.org/10.3802/jgo.2019.30.e18

Abstract

Nineteen topics were selected as major clinical research advances in gynecologic oncology in 2018. For cervical cancer, the importance of human papillomavirus (HPV) testing alone as primary cervical cancer screening method and negative survival impact of minimally invasive surgery in early-stage cervical cancer were addressed. For ovarian cancer, cost-effectiveness of genetic testing to prevent cancer, use of analgesics and oral pill to reduce cancer risk, efficacy of secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, update in the use of poly (ADP-ribose) polymerase inhibitor, and efficacy of anti-angiogenic targeted treatments, including bevacizumab and tyrosine kinase inhibitors, were reviewed. For corpus cancer, sentinel lymph node mapping technique, adjuvant therapy in high-risk endometrial cancer (PORTEC-3), and targeted therapy in recurrent disease were covered. For the field of radiation oncology, survival outcomes of chemoradiation compared with chemotherapy alone in metastatic cervical cancer and new findings regarding the use of neoadjuvant chemotherapy in locally advanced cervical cancer were introduced. Lastly, for breast cancer, the use of talazoparib in patients with germline BRCA1/2 mutation, ovarian suppression for premenopausal patients, adjuvant chemotherapy guided by 21-gene assay, and combination therapy of atezolizumab and nab-paclitaxel for triple-negative cancer as well as promising overall survival results of palbociclib and fulvestrant in advanced breast cancer were briefly mentioned.

Keyword

Minimally Invasive Surgical Procedures; Uterine Cervical Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Ovarian Neoplasms; Endometrial Neoplasms; Breast Neoplasms

MeSH Terms

Analgesics
Bevacizumab
Breast Neoplasms
Chemotherapy, Adjuvant
Drug Therapy
Endometrial Neoplasms
Female
Genetic Testing
Humans
Lymph Nodes
Mass Screening
Methods
Minimally Invasive Surgical Procedures
Ovarian Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors
Protein-Tyrosine Kinases
Radiation Oncology
Uterine Cervical Neoplasms
Analgesics
Bevacizumab
Poly(ADP-ribose) Polymerase Inhibitors
Protein-Tyrosine Kinases