Ann Dermatol.  2019 Aug;31(Suppl):S29-S31. 10.5021/ad.2019.31.S.S29.

Basal Cell Carcinoma Arising within Seborrheic Keratosis

• Lee CY
• Sung JY
• Jeong KH
• Lee MH

• KMID: 2456669
• DOI: http://doi.org/10.5021/ad.2019.31.S.S29

Abstract

No abstract available.

MeSH Terms

Carcinoma, Basal Cell*
Keratosis, Seborrheic*

Figure

• 

  Fig. 1 (A) Verrucous surfaced brownish plaque, measuring 3×4 cm in diameter, with crust and ulceration. Histological analysis of the (B) peripheral margin showed epidermal hyperkeratosis, acanthosis, papillomatosis, and pseudo-horn/horn cyst and (C) crusted lesion revealed proliferation of atypical basaloid cell showing peripheral palisading and cleft between the epithelium and the stroma (H&E: B, C, ×40).

• 

  Fig. 2 (A) Scanning view of excision specimen (H&E, scanning view). Histological analysis of total excised lesion showed (B) basal cell carcinoma (BCC) in the crusted lesion, (D) seborrheic keratosis (SK) in the peripheral margin and (C) mixed pathologic zone between BCC and SK (H&E: B~D, ×100). (E) Diffuse positive staining with CK19 of BCC compared with (G) SK in the peripheral margin, and (F) partial positive staining with CK19 of mixed pathologic zone (CK19: E~G, ×100).

Reference

1. Shibao K, Okiyama N, Tanaka R, Maruyama H, Fujisawa Y, Fujimoto M. Nodulocystic basal cell carcinoma arising directly from a seborrheic keratosis: a rare case report. Indian J Dermatol. 2016; 61:443–445.

2. Terada T, Kamo M, Baba Y, Sugiura M. Microinvasive squamous cell carcinoma arising within seborrheic keratosis. Cutis. 2012; 90:176–178.

3. Lim C. Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol. 2006; 47:109–113.

4. Cascajo CD, Reichel M, Sánchez JL. Malignant neoplasms associated with seborrheic keratoses. An analysis of 54 cases. Am J Dermatopathol. 1996; 18:278–282.

5. Nindl M, Nakagawa H, Furue M, Ishibashi Y. Simple epithelial cytokeratin-expression in seborrheic keratosis. J Cutan Pathol. 1992; 19:415–422.