Ann Dermatol.  2019 Oct;31(5):563-566. 10.5021/ad.2019.31.5.563.

Unusual Presentation of Subcutaneous Phaeohyphomycosis by Alternaria alternate

Affiliations
  • 1Department of Infectious Disease, Keimyung University Dongsan Medical Center, Daegu, Korea. 121rsy@dsmc.or.kr

Abstract

The Alternaria species are dematiaceous fungi. Human infection due to dematiaceous fungi is uncommon. Most reported cases of alternariosis have occurred in patients with immunodeficiency. The majority of cases were solid-organ transplantation recipients. Cutaneous alternariosis lesions are usually asymptomatic solitary nodules, plaques of ulcers or subcutaneous cysts. Here we report a case of a 77-year-old female who presented with hemorrhagic skin necrosis in right arm that had developed from hemorrhagic bullae. Her prior medical history included iatrogenic Cushing's syndrome, hypertension, interstitial lung disease and congestive heart failure. Following administration of itraconazole, her lesions improved.

Keyword

Alternaria; Phaeohyphomycosis

MeSH Terms

Aged
Alternaria*
Alternariosis
Arm
Cushing Syndrome
Female
Fungi
Heart Failure
Humans
Hypertension
Itraconazole
Lung Diseases, Interstitial
Necrosis
Phaeohyphomycosis*
Skin
Ulcer
Itraconazole

Figure

  • Fig. 1 (A) Tender multiple ulceration and several hemorrhagic bullae with erythematous base on the right forearm area. (B) Diffuse subcutaneous swelling with reticular enhancement was noted. Swelling of dermis and the peripheral region is noted. These lesions show heterogenous signal intensity on both T1WI and T2WI without significant enhancement.

  • Fig. 2 Histological examination of a biopsy specimen from a right forearm. (A, B) Acute suppurative dermal inflammation with granulomatous inflammation (Hematoxylin & eosin stain, A: ×10, B: ×40). (C) Gomori-methenamine silver stain showed branched fungal hyphae (×400). (D) Fontana-Masson stain showed the presence of melanin pigment in the fungal wall (×400).


Reference

1. Iwatsu T. Cutaneous alternariosis. Arch Dermatol. 1988; 124:1822–1825. PMID: 3190258.
Article
2. Ajello L, Georg LK, Steigbigel RT, Wang CJ. A case of phaeohyphomycosis caused by a new species of Phialophora. Mycologia. 1974; 66:490–498. PMID: 4601425.
Article
3. Kim MS, Kim JK, Lee MW, Moon KC, Kim BJ, Son SW, et al. Epidemiology of deep cutaneous fungal infections in Korea (2006-2010). J Dermatol. 2015; 42:962–966. PMID: 26105506.
Article
4. Romano C, Vanzi L, Massi D, Difonzo EM. Subcutaneous alternariosis. Mycoses. 2005; 48:408–412. PMID: 16262877.
Article
5. Uenotsuchi T, Moroi Y, Urabe K, Fukagawa S, Tsuji G, Matsuda T, et al. Cutaneous alternariosis with chronic granulomatous disease. Eur J Dermatol. 2005; 15:406–408. PMID: 16172055.
6. Magina S, Lisboa C, Santos P, Oliveira G, Lopes J, Rocha M, et al. Cutaneous alternariosis by Alternaria chartarum in a renal transplanted patient. Br J Dermatol. 2000; 142:1261–1262. PMID: 10848774.
Article
7. Laumaillé C, Le Gall F, Degeilh B, Guého E, Huerre M. [Cutaneous Alternaria infectoria infection after liver transplantation]. Ann Pathol. 1998; 18:192–194. French. PMID: 9706345.
8. Wiest PM, Wiese K, Jacobs MR, Morrissey AB, Abelson TI, Witt W, et al. Alternaria infection in a patient with acquired immunodeficiency syndrome: case report and review of invasive alternaria infections. Rev Infect Dis. 1987; 9:799–803. PMID: 3326127.
Article
9. Akman A, Sakalli Cakcak D, Ozhak Baysan B, Yazisiz V, Terzioglu E, Ciftcioglu MA, et al. Cutaneous alternariosis in a patient with systemic lupus erythematosus. Lupus. 2007; 16:993–996. PMID: 18042595.
Article
10. Elder DE. Lever's histopathology of the skin. 11th ed. Philadelphia: Lippincott William & Wilkins;2015. p. 739–740.
11. Lyke KE, Miller NS, Towne L, Merz WG. A case of cutaneous ulcerative alternariosis: rare association with diabetes mellitus and unusual failure of itraconazole treatment. Clin Infect Dis. 2001; 32:1178–1187. PMID: 11283807.
Article
12. Hsiao CT, Lin LJ, Shiao CJ, Hsiao KY, Chen IC. Hemorrhagic bullae are not only skin deep. Am J Emerg Med. 2008; 26:316–319. PMID: 18358943.
Article
13. Hsu CC, Chang SS, Lee PC, Chao SC. Cutaneous alternariosis in a renal transplant recipient: a case report and literature review. Asian J Surg. 2015; 38:47–57. PMID: 25554667.
Article
14. Sohng SH, Choi JS, Kim YW, Kim BS, Choi JH, Shin DH. A case of cutaneous infection by Alternaria alternata. Korean J Med Mycol. 2014; 19:76–81.
15. Acland KM, Hay RJ, Groves R. Cutaneous infection with Alternaria alternata complicating immunosuppression: successful treatment with itraconazole. Br J Dermatol. 1998; 138:354–356. PMID: 9602891.
16. Gilaberte M, Bartralot R, Torres JM, Reus FS, Rodríguez V, Alomar A, et al. Cutaneous alternariosis in transplant recipients: clinicopathologic review of 9 cases. J Am Acad Dermatol. 2005; 52:653–659. PMID: 15793517.
Article
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