Korean J Pain.  2019 Jul;32(3):147-159. 10.3344/kjp.2019.32.3.147.

Lumbar foraminal neuropathy: an update on non-surgical management

Affiliations
  • 1New Jersey Pain Medicine for the Difficult and Failed Pain, Robert Wood Johnson University Hospital Rahway, Rahway, NJ, USA. choiyomd@hotmail.com

Abstract

Lumbar foraminal pathology causing entrapment of neurovascular contents and radicular symptoms are commonly associated with foraminal stenosis. Foraminal neuropathy can also be derived from inflammation of the neighboring lateral recess or extraforaminal spaces. Conservative and interventional therapies have been used for the treatment of foraminal inflammation, fibrotic adhesion, and pain. This update reviews the anatomy, pathophysiology, clinical presentation, diagnosis, and current treatment options of foraminal neuropathy.

Keyword

Constriction, Pathologic; Decompression; Electric Stimulation; Fibrosis; Foraminotomy; Ganglia, Spinal; Inflammation; Lumbosacral Region; Pain Management; Radiculopathy; Spinal Nerve Roots

MeSH Terms

Constriction, Pathologic
Decompression
Diagnosis
Electric Stimulation
Fibrosis
Foraminotomy
Ganglia, Spinal
Inflammation
Lumbosacral Region
Pain Management
Pathology
Radiculopathy
Spinal Nerve Roots

Figure

  • Fig. 1 Superoposterior view of the foramen. Internal (green), intraforaminal (red), and external (blue) zones.

  • Fig. 2 The lateral view of foramen with ligaments, nerve root (NR), and dorsal root ganglion (DRG).

  • Fig. 3 Epiduroscopic findings of inflammation. (A) Mild inflammation, (B) moderate inflammation with fibrosis, and (C) extensive inflammation with granulation and fibrosis.

  • Fig. 4 Epiduroscopic findings of inflammation fibrosis complex. (A) Epidural space is filled with gelatinous exudates and fibrosis, (B) fibrotic bands and meshes, and (C) membranous fibrosis.

  • Fig. 5 Lateral view of foraminal nerve entrapment. (A) Inflamed swollen nerve in normal foramen and (B) compressed nerve in foraminal stenosis. NR: nerve root, DRG: dorsal root ganglion.


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Reference

1. Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A, et al. Spinal stenosis prevalence and association with symptoms: the Framingham Study. Spine J. 2009; 9:545–50. DOI: 10.1016/j.spinee.2009.03.005. PMID: 19398386. PMCID: 3775665.
Article
2. Annertz M, Jönsson B, Strömqvist B, Holtås S. No relationship between epidural fibrosis and sciatica in the lumbar postdiscectomy syndrome. A study with contrast-enhanced magnetic resonance imaging in symptomatic and asymptomatic patients. Spine (Phila Pa 1976). 1995; 20:449–53. DOI: 10.1097/00007632-199502001-00007. PMID: 7747228.
3. Hasue M, Kikuchi S, Sakuyama Y, Ito T. Anatomic study of the interrelation between lumbosacral nerve roots and their surrounding tissues. Spine (Phila Pa 1976). 1983; 8:50–8. DOI: 10.1097/00007632-198301000-00010. PMID: 6867859.
Article
4. Zhao Q, Zhong E, Shi B, Li Y, Sun C, Ding Z. The morphology and clinical significance of the intraforaminal ligaments at the L5-S1 levels. Spine J. 2016; 16:1001–6. DOI: 10.1016/j.spinee.2016.03.048. PMID: 27060710.
Article
5. Amonoo-Kuofi HS, el-Badawi MG, Fatani JA. Ligaments associated with lumbar intervertebral foramina. 1. L1 to L4. J Anat. 1988; 156:177–83. PMID: 3417545. PMCID: 1261921.
6. Yuan SG, Wen YL, Zhang P, Li YK. Ligament, nerve, and blood vessel anatomy of the lateral zone of the lumbar intervertebral foramina. Int Orthop. 2015; 39:2135–41. DOI: 10.1007/s00264-015-2831-6. PMID: 26130281.
Article
7. Moon HS, Kim YD, Song BH, Cha YD, Song JH, Lee MH. Position of dorsal root ganglia in the lumbosacral region in patients with radiculopathy. Korean J Anesthesiol. 2010; 59:398–402. DOI: 10.4097/kjae.2010.59.6.398. PMID: 21253377. PMCID: PMC3022133.
Article
8. Arnoldi CC, Brodsky AE, Cauchoix J, Crock HV, Dommisse GF, Edgar MA, et al. Lumbar spinal stenosis and nerve root entrapment syndromes. Definition and classification. Clin Orthop Relat Res. 1976; 115:4–5. PMID: 1253495.
9. Jenis LG, An HS. Spine update. Lumbar foraminal stenosis. Spine (Phila Pa 1976). 2000; 25:389–94. DOI: 10.1097/00007632-200002010-00022. PMID: 10703115.
10. Kirkaldy-Willis WH, Farfan HF. Instability of the lumbar spine. Clin Orthop Relat Res. 1982; 165:110–23. PMID: 6210480.
Article
11. Hasegawa T, An HS, Haughton VM, Nowicki BH. Lumbar foraminal stenosis: critical heights of the intervertebral discs and foramina. A cryomicrotome study in cadavera. J Bone Joint Surg Am. 1995; 77:32–8. DOI: 10.2106/00004623-199501000-00005. PMID: 7822353.
12. Fujiwara A, An HS, Lim TH, Haughton VM. Morphologic changes in the lumbar intervertebral foramen due to flexionextension, lateral bending, and axial rotation: an in vitro anatomic and biomechanical study. Spine (Phila Pa 1976). 2001; 26:876–82. DOI: 10.1097/00007632-200104150-00010. PMID: 11317109.
13. Inufusa A, An HS, Lim TH, Hasegawa T, Haughton VM, Nowicki BH. Anatomic changes of the spinal canal and intervertebral foramen associated with flexion-extension movement. Spine (Phila Pa 1976). 1996; 21:2412–20. DOI: 10.1097/00007632-199611010-00002. PMID: 8923625.
Article
14. Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, et al. Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. Osteoarthritis Cartilage. 2013; 21:783–8. DOI: 10.1016/j.joca.2013.02.656. PMID: 23473979.
Article
15. de Peretti F, Micalef JP, Bourgeon A, Argenson C, Rabischong P. Biomechanics of the lumbar spinal nerve roots and the first sacral root within the intervertebral foramina. Surg Radiol Anat. 1989; 11:221–5. DOI: 10.1007/BF02337826. PMID: 2588099.
Article
16. McCarron RF, Wimpee MW, Hudkins PG, Laros GS. The inflammatory effect of nucleus pulposus. A possible element in the pathogenesis of low-back pain. Spine (Phila Pa 1976). 1987; 12:760–4. DOI: 10.1097/00007632-198710000-00009. PMID: 2961088.
17. Qian Y, Qin A, Zheng MH. Transforaminal ligament may play a role in lumbar nerve root compression of foraminal stenosis. Med Hypotheses. 2011; 77:1148–9. DOI: 10.1016/j.mehy.2011.09.025. PMID: 22014758.
Article
18. Sapunar D, Kostic S, Banozic A, Puljak L. Dorsal root ganglion - a potential new therapeutic target for neuropathic pain. J Pain Res. 2012; 5:31–8. DOI: 10.2147/JPR.S26603. PMID: 22375099. PMCID: 3287412.
19. Weinstein J. Report of the 1985 ISSLS Traveling Fellowship. Mechanisms of spinal pain. The dorsal root ganglion and its role as a mediator of low-back pain. Spine (Phila Pa 1976). 1986; 11:999–1001. DOI: 10.1097/00007632-198612000-00005. PMID: 2437662.
Article
20. Rydevik B, Brown MD, Lundborg G. Pathoanatomy and pathophysiology of nerve root compression. Spine (Phila Pa 1976). 1984; 9:7–15. DOI: 10.1097/00007632-198401000-00004. PMID: 6372124.
Article
21. Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol. 1999; 82:3347–58. DOI: 10.1152/jn.1999.82.6.3347. PMID: 10601466.
Article
22. Wieseler-Frank J, Maier SF, Watkins LR. Glial activation and pathological pain. Neurochem Int. 2004; 45:389–95. DOI: 10.1016/j.neuint.2003.09.009. PMID: 15145553.
Article
23. Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am. 1990; 72:403–8. DOI: 10.2106/00004623-199072030-00013. PMID: 2312537.
Article
24. Hilibrand AS, Rand N. Degenerative lumbar stenosis: diagnosis and management. J Am Acad Orthop Surg. 1999; 7:239–49. DOI: 10.5435/00124635-199907000-00004. PMID: 10434078.
Article
25. Wiesel SW, Tsourmas N, Feffer HL, Citrin CM, Patronas N. A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine (Phila Pa 1976). 1984; 9:549–51. DOI: 10.1097/00007632-198409000-00003. PMID: 6495024.
26. Lee S, Lee JW, Yeom JS, Kim KJ, Kim HJ, Chung SK, et al. A practical MRI grading system for lumbar foraminal stenosis. AJR Am J Roentgenol. 2010; 194:1095–8. DOI: 10.2214/AJR.09.2772. PMID: 20308517.
Article
27. Bolender NF, Schönström NS, Spengler DM. Role of computed tomography and myelography in the diagnosis of central spinal stenosis. J Bone Joint Surg Am. 1985; 67:240–6. DOI: 10.2106/00004623-198567020-00009. PMID: 3968115.
Article
28. Haig AJ, Tong HC, Yamakawa KS, Quint DJ, Hoff JT, Chiodo A, et al. The sensitivity and specificity of electrodiagnostic testing for the clinical syndrome of lumbar spinal stenosis. Spine (Phila Pa 1976). 2005; 30:2667–76. DOI: 10.1097/01.brs.0000188400.11490.5f. PMID: 16319753.
Article
29. Onel D, Sari H, Dönmez C. Lumbar spinal stenosis: clinical/radiologic therapeutic evaluation in 145 patients. Conservative treatment or surgical intervention? Spine (Phila Pa 1976). 1993; 18:291–8. DOI: 10.1097/00007632-199302000-00020. PMID: 8441947.
30. Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008; 24:479–96. DOI: 10.1097/AJP.0b013e31816b2f43. PMID: 18574358.
31. Angst MS, Clark JD. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006; 104:570–87. DOI: 10.1097/00000542-200603000-00025. PMID: 16508405.
Article
32. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, et al. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004; 24:7353–65. DOI: 10.1523/JNEUROSCI.1850-04.2004. PMID: 15317861.
Article
33. Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal. 2007; 7:98–111. DOI: 10.1100/tsw.2007.230. PMID: 17982582. PMCID: 5901235.
Article
34. Kissin I. Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety? J Pain Res. 2013; 6:513–29. DOI: 10.2147/JPR.S47182. PMID: 23874119. PMCID: 3712997.
35. Bonnet U, Richter EL, Isbruch K, Scherbaum N. On the addictive power of gabapentinoids: a mini-review. Psychiatr Danub. 2018; 30:142–9. DOI: 10.24869/psyd.2018.142. PMID: 29930223.
Article
36. Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W. Gabapentin, opioids, and the risk of opioid-related death: a population-based nested case-control study. PLoS Med. 2017; 14:e1002396. DOI: 10.1371/journal.pmed.1002396. PMID: 28972983. PMCID: 5626029.
Article
37. Niesters M, Martini C, Dahan A. Ketamine for chronic pain: risks and benefits. Br J Clin Pharmacol. 2014; 77:357–67. DOI: 10.1111/bcp.12094. PMCID: 4014022.
Article
38. Sigtermans MJ, van Hilten JJ, Bauer MC, Arbous MS, Marinus J, Sarton EY, et al. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain. 2009; 145:304–11. DOI: 10.1016/j.pain.2009.06.023. PMID: 19604642.
Article
39. Jo D, Chapman CR, Light AR. Glial mechanisms of neuropathic pain and emerging interventions. Korean J Pain. 2009; 22:1–15. DOI: 10.3344/kjp.2009.22.1.1.
Article
40. Whitman JM, Flynn TW, Childs JD, Wainner RS, Gill HE, Ryder MG, et al. A comparison between two physical therapy treatment programs for patients with lumbar spinal stenosis: a randomized clinical trial. Spine (Phila Pa 1976). 2006; 31:2541–9. DOI: 10.1097/01.brs.0000241136.98159.8c. PMID: 17047542.
41. Johansson A, Hao J, Sjölund B. Local corticosteroid application blocks transmission in normal nociceptive C-fibres. Acta Anaesthesiol Scand. 1990; 34:335–8. DOI: 10.1111/j.1399-6576.1990.tb03097.x. PMID: 2167604.
Article
42. Abdi S, Datta S, Trescot AM, Schultz DM, Adlaka R, Atluri SL, et al. Epidural steroids in the management of chronic spinal pain: a systematic review. Pain Physician. 2007; 10:185–212. PMID: 17256030.
43. Kim D, Brown J. Efficacy and safety of lumbar epidural dexamethasone versus methylprednisolone in the treatment of lumbar radiculopathy: a comparison of soluble versus particulate steroids. Clin J Pain. 2011; 27:518–22. DOI: 10.1097/AJP.0b013e31820c53e0. PMID: 21562412.
44. Lee JH, Kim DH, Kim DH, Shin KH, Park SJ, Lee GJ, et al. Comparison of clinical efficacy of epidural injection with or without steroid in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018; 21:449–68. PMID: 30282390.
45. U.S. Food and Drug Administration. FDA drug safety communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain [Internet]. Silver Spring: U.S. FDA;2014. [cited 2019 May 3]. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requires-label-changes-warn-rare-seriousneurologic-problems-after.
46. Rathmell JP, Benzon HT, Dreyfuss P, Huntoon M, Wallace M, Baker R, et al. Safeguards to prevent neurologic complications after epidural steroid injections: consensus opinions from a multidisciplinary working group and national organizations. Anesthesiology. 2015; 122:974–84. DOI: 10.1097/ALN.0000000000000614. PMID: 25668411.
47. Cooper G, Lutz GE, Boachie-Adjei O, Lin J. Effectiveness of transforaminal epidural steroid injections in patients with degenerative lumbar scoliotic stenosis and radiculopathy. Pain Physician. 2004; 7:311–7. PMID: 16858467.
48. Rahatli FK, Harman A, Boyvat F, Zararsiz G. Comparison of transforaminal and interlaminar epidural steroid injection in managing lumbar radiculopathy. Biomed Res. 2017; 28:2204–8.
49. Manchikanti L, Cash KA, Pampati V, Damron KS, McManus CD. Evaluation of lumbar transforaminal epidural injections with needle placement and contrast flow patterns: a prospective, descriptive report. Pain Physician. 2004; 7:217–23. PMID: 16868595.
50. Cyteval C, Fescquet N, Thomas E, Decoux E, Blotman F, Taourel P. Predictive factors of efficacy of periradicular corticosteroid injections for lumbar radiculopathy. AJNR Am J Neuroradiol. 2006; 27:978–82. PMID: 16687527.
51. Choi YK. Spinal epiduroscopy as an educational tool. Korean J Pain. 2018; 31:132–4. DOI: 10.3344/kjp.2018.31.2.132. PMID: 29686812. PMCID: 5904348.
Article
52. Bosscher HA, Heavner JE. Incidence and severity of epidural fibrosis after back surgery: an endoscopic study. Pain Pract. 2010; 10:18–24. DOI: 10.1111/j.1533-2500.2009.00311.x. PMID: 19735365.
Article
53. Park Y, Lee WY, Ahn JK, Nam HS, Lee KH. Percutaneous adhesiolysis versus transforaminal epidural steroid injection for the treatment of chronic radicular pain caused by lumbar foraminal spinal stenosis: a retrospective comparative study. Ann Rehabil Med. 2015; 39:941–9. DOI: 10.5535/arm.2015.39.6.941. PMID: 26798608. PMCID: PMC4720770.
Article
54. Park CH, Lee SH. Effectiveness of percutaneous transforaminal adhesiolysis in patients with lumbar neuroforaminal spinal stenosis. Pain Physician. 2013; 16:E37–43. PMID: 23340543.
55. Racz GB, Holubec JT. Lysis of adhesions in the epidural space. Techniques of neurolysis. Racz GB, editor. Boston: Springer;1989. p. 57–72. DOI: 10.1007/978-1-4899-6721-3_6.
Article
56. Anderson SR, Racz GB, Heavner J. Evolution of epidural lysis of adhesions. Pain Physician. 2000; 3:262–70. PMID: 16906184.
Article
57. Lee JH, Lee SH. Clinical effectiveness of percutaneous adhesiolysis using Navicath for the management of chronic pain due to lumbosacral disc herniation. Pain Physician. 2012; 15:213–21. PMID: 22622905.
58. Devulder J, Bogaert L, Castille F, Moerman A, Rolly G. Relevance of epidurography and epidural adhesiolysis in chronic failed back surgery patients. Clin J Pain. 1995; 11:147–50. DOI: 10.1097/00002508-199506000-00011. PMID: 7549172.
Article
59. Helm Ii S, Benyamin RM, Chopra P, Deer TR, Justiz R. Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review. Pain Physician. 2012; 15:E435–62. PMID: 22828693.
60. Gerdesmeyer L, Wagenpfeil S, Birkenmaier C, Veihelmann A, Hauschild M, Wagner K, et al. Percutaneous epidural lysis of adhesions in chronic lumbar radicular pain: a randomized, double-blind, placebo-controlled trial. Pain Physician. 2013; 16:185–96. PMID: 23703406.
61. Jamison DE, Hsu E, Cohen SP. Epidural adhesiolysis: an evidence-based review. J Neurosurg Sci. 2014; 58:65–76. PMID: 24819483.
62. Lee JH, Lee SH. Clinical effectiveness of percutaneous adhesiolysis and predictive factors of treatment efficacy in patients with lumbosacral spinal stenosis. Pain Med. 2013; 14:1497–504. DOI: 10.1111/pme.12180. PMID: 23802996.
Article
63. Saberski LR, Kitahata LM. Direct visualization of the lumbosacral epidural space through the sacral hiatus. Anesth Analg. 1995; 80:839–40. PMID: 7893046.
Article
64. Hayek SM, Helm S, Benyamin RM, Singh V, Bryce DA, Smith HS. Effectiveness of spinal endoscopic adhesiolysis in post lumbar surgery syndrome: a systematic review. Pain Physician. 2009; 12:419–35. PMID: 19305488.
65. Takeshima N, Miyakawa H, Okuda K, Hattori S, Hagiwara S, Takatani J, et al. Evaluation of the therapeutic results of epiduroscopic adhesiolysis for failed back surgery syndrome. Br J Anaesth. 2009; 102:400–7. DOI: 10.1093/bja/aen383. PMID: 19164308.
Article
66. Raffaeli W, Righetti D, Andruccioli J, Sarti D. Epiduroscopy and radiofrequency technique: the Raffaeli-Righetti technique. Pain Clin. 2007; 19:185–91. DOI: 10.1179/016911107X376927.
Article
67. Kim SH, Choi WJ, Suh JH, Jeon SR, Hwang CJ, Koh WU, et al. Effects of transforaminal balloon treatment in patients with lumbar foraminal stenosis: a randomized, controlled, double-blind trial. Pain Physician. 2013; 16:213–24. PMID: 23703408.
68. Choi SS, Joo EY, Hwang BS, Lee JH, Lee G, Suh JH, et al. A novel balloon-inflatable catheter for percutaneous epidural adhesiolysis and decompression. Korean J Pain. 2014; 27:178–85. DOI: 10.3344/kjp.2014.27.2.178. PMID: 24748948. PMCID: 3990828.
Article
69. Transfeldt EE, Robertson D, Bradford DS. Ligaments of the lumbosacral spine and their role in possible extraforaminal spinal nerve entrapment and tethering. J Spinal Disord. 1993; 6:507–12. DOI: 10.1097/00002517-199306060-00006. PMID: 8130399.
Article
70. Lee SC, Kim WJ, Lee CS, Moon JY. Effectiveness of percutaneous lumbar extraforaminotomy in patients with lumbar foraminal spinal stenosis: a prospective, singlearmed, observational pilot study. Pain Med. 2017; 18:1975–86. DOI: 10.1093/pm/pnw355. PMID: 28371922.
Article
71. Yoo Y, Moon JY, Yoon S, Kwon SM, Sim SE. Clinical outcome of percutaneous lumbar foraminoplasty using a safety-improved device in patients with lumbar foraminal spinal stenosis. Medicine (Baltimore). 2019; 98:e15169. DOI: 10.1097/MD.0000000000015169. PMID: 30985699. PMCID: PMC6485750.
Article
72. Sluijter ME, Cosman ER, Rittman WB III, van Kleef M. The effects of pulsed radiofrequency fields applied to the dorsal root ganglion: a preliminary report. Pain Clin. 1998; 11:109–17.
73. Chua NH, Vissers KC, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications-a review. Acta Neurochir (Wien). 2011; 153:763–71. DOI: 10.1007/s00701-010-0881-5. PMID: 21116663. PMCID: PMC3059755.
Article
74. Higuchi Y, Nashold BS Jr, Sluijter M, Cosman E, Pearlstein RD. Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons. Neurosurgery. 2002; 50:850–5. DOI: 10.1097/00006123-200204000-00030. PMID: 11904038.
Article
75. Ding Y, Li H, Zhu Y, Yao P, Zhao G. Transforaminal epidural steroid injection combined with pulsed radio frequency on spinal nerve root for the treatment of lumbar disc herniation. J Pain Res. 2018; 11:1531–9. DOI: 10.2147/JPR.S174318. PMID: 30147357. PMCID: 6097521.
Article
76. Shealy CN, Mortimer JT, Reswick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg. 1967; 46:489–91. DOI: 10.1213/00000539-196707000-00025. PMID: 4952225.
77. Song JJ, Popescu A, Bell RL. Present and potential use of spinal cord stimulation to control chronic pain. Pain Physician. 2014; 17:235–46. PMID: 24850105.
78. Kamihara M, Nakano S, Fukunaga T, Ikeda K, Tsunetoh T, Tanada D, et al. Spinal cord stimulation for treatment of leg pain associated with lumbar spinal stenosis. Neuromodulation. 2014; 17:340–4. DOI: 10.1111/ner.12092. PMID: 23919348.
Article
79. Arle JE, Mei L, Carlson KW, Shils JL. High-frequency stimulation of dorsal column axons: potential underlying mechanism of paresthesia-free neuropathic pain relief. Neuromodulation. 2016; 19:385–97. DOI: 10.1111/ner.12436. PMID: 27145196.
Article
80. Sun FT, Morrell MJ. Closed-loop neurostimulation: the clinical experience. Neurotherapeutics. 2014; 11:553–63. DOI: 10.1007/s13311-014-0280-3. PMID: 24850309. PMCID: 4121459.
Article
81. Veizi E, Hayek SM, North J, Brent Chafin T, Yearwood TL, Raso L, et al. Spinal Cord Stimulation (SCS) with anatomically guided (3D) neural targeting shows superior chronic axial low back pain relief compared to traditional SCS-LUMINA study. Pain Med. 2017; 18:1534–48. PMID: 28108641.
Article
82. Remacle T, Gilis N, Mauviel S, Remacle JM. Treating low back pain in failed back surgery patients with multicolumn-lead spinal cord stimulation. J Vis Exp. 2018; (136):56804. DOI: 10.3791/56804. PMID: 30010647. PMCID: PMC6101993.
Article
83. Deer TR, Grigsby E, Weiner RL, Wilcosky B, Kramer JM. A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. Neuromodulation. 2013; 16:67–71. DOI: 10.1111/ner.12013. PMID: 23240657.
Article
84. Liem L, Russo M, Huygen FJ, Van Buyten JP, Smet I, Verrills P, et al. One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain. Neuromodulation. 2015; 18:41–8. 48–9. DOI: 10.1111/ner.12228. PMID: 25145467.
Article
85. Krames ES. The dorsal root ganglion in chronic pain and as a target for neuromodulation: a review. Neuromodulation. 2015; 18:24–32. DOI: 10.1111/ner.12247. PMID: 25354206.
Article
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