Tissue Eng Regen Med.  2019 Aug;16(4):357-363. 10.1007/s13770-018-00176-6.

Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment

Affiliations
  • 1Research Institute for Integrative Regenerative Biomedical Engineering, Dongguk University, Goyang 10326, Republic of Korea. gunil@duih.org

Abstract

BACKGROUND
Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects.
METHODS
Current progress of IA injection therapy and the author's perspective on this issue are described narratively.
RESULTS
It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy.
CONCLUSION
Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.

Keyword

Cell therapy; Intra-articular injection; Cartilage regeneration; Osteoarthritis treatment

MeSH Terms

Arthritis
Cartilage, Articular
Cell- and Tissue-Based Therapy*
Cost-Benefit Analysis
Hip
Humans
Hyaluronic Acid
Injections, Intra-Articular*
Joints
Knee
Osteoarthritis*
Prospective Studies
Regeneration
Hyaluronic Acid
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