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Hypoxia Pretreatment Promotes Chondrocyte Differentiation of Human Adipose-Derived Stem Cells via Vascular Endothelial Growth Factor

Hwang OK, Noh YW, Hong JT, Lee JW

BACKGROUND: Human adipose tissue-derived stem cells (ADSCs) are attractive multipotent stem cell sources with therapeutic potential in various fields requiring repair and regeneration, such as acute and chronically damaged tissues....
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Evaluation of Collagen Gel-Associated Human Nasal Septum- Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair

Lim MH, Jeun JH, Kim DH, Park SH, Kim SJ, Lee WS, Hwang SH, Lim JY, Kim SW

BACKGROUND: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived...
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Current Update of Cartilage Regeneration Using Stem Cells in Osteoarthritis

Seon JK, Choi IS, Ko JW

Osteoarthritis is a disease characterized by the progression of articular cartilage erosion, that increases pain during joint motion and reduces the ability to withstand mechanical stress, which in turn limits...
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Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment

Im GI

BACKGROUND: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected...
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Mechanically Reinforced Extracellular Matrix Scaffold for Application of Cartilage Tissue Engineering

Oh HJ, Kim SH, Cho JH, Park SH, Min BH

Scaffolds with cartilage-like environment and suitable physical properties are critical for tissue-engineered cartilage repair. In this study, decellularized porcine cartilage-derived extracellular matrix (ECM) was utilized to fabricate ECM scaffolds. Mechanically...
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Non-contact Coculture Reveals a Comprehensive Response of Chondrocytes Induced by Mesenchymal Stem Cells Through Trophic Secretion

Xu L, Wu Y, Liu Y, Zhou Y, Ye Z, Tan WS

Coculture between mesenchymal stem cells (MSCs) and chondrocytes has significant implications in cartilage regeneration. However, a conclusive understanding remains elusive. Previously, we reported that rabbit bone marrow-derived MSCs (rbBMSCs) could...
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Magnetic Resonance Imaging (MRI) of a Hypertrophy of Cartilage and Simultaneous Regeneration of a Damaged Meniscus after Autologous Bone Marrow Aspirates Concentrate (BMAC) Transplantation: a Case Report and Literature Review

Bae SH, Kim HJ, Oh E, Hwang J, Hong SS, Hwang JH

Bone marrow aspirates concentrate (BMAC) transplantation is a well-known technique for cartilage regeneration with good clinical outcomes for symptoms in patients with osteoarthritis (OA). Magnetic resonance imaging (MRI) has an...
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Alginate-Hyaluronic Acid-Collagen Composite Hydrogel Favorable for the Culture of Chondrocytes and Their Phenotype Maintenance

Mahapatra , Jin GZ, Kim HW

Articular cartilage has limited regeneration capacity, thus significant challenge has been made to restore the functions. The development of hydrogels that can encapsulate and multiply cells, and then effectively maintain...
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Chondrogenic Effect of Transplanted Type I Collagen Scaffold within Subperichondrial Cartilage Defect

Lee HG, Son DG, Han KH, Kim JH, Lee SY

  • KMID: 2203416
  • J Korean Soc Plast Reconstr Surg.
  • 2005 Jul;32(4):521-528.
The purpose of this research is to find out the degree of cartilage regeneration by inserting the atelo- collagen scaffold obtained from dermis of a calf on cartilage defect site....
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Optical Coherence Tomography Analysis of the Rabbit Articular Cartilage after Chondrocyte Transplantation

Han CW, Kim JY, Choi WS, Kim CK, Lee JH, Pan Y

  • KMID: 2104896
  • J Korean Orthop Res Soc.
  • 2002 Oct;5(2):93-99.
PURPOSE: To evaluate the ability of optical coherence tomography (OCT) to provide real-time, high-resolution structural analysis of the full thickness rabbit articular repair tissue following chondrocyte transplantation. MATERIALS AND METHODS: Full...
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The Effect of an Artificial Dermis on Chondrogenesis from Perichondrium

Kim DG, Shin DP, Park JW, Cho BC, Baik BS, Yoon KT

  • KMID: 2119713
  • J Korean Soc Plast Reconstr Surg.
  • 2001 Jan;28(1):37-43.
The purpose of this study is to investigate the effect of artificial dermis(Terudermis(R)) on cartilage induction from perichondrium. A total of 24 rabbits were used and divided into control(n =...
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