Ann Clin Neurophysiol.  2018 Jul;20(2):97-100. 10.14253/acn.2018.20.2.97.

Cefepime-induced nonconvulsive status epilepticus in a hemodialysis patient

• Lee YJ
• Park BS
• Park KM
• Kim IH
• Park JH
• Park SH
• Kim YW

• KMID: 2454713
• DOI: http://doi.org/10.14253/acn.2018.20.2.97

Abstract

Nonconvulsive status epilepticus (NCSE) is an unusual complication in patients treated with cefepime. An 82-year-old woman on maintenance hemodialysis was given cefepime for pneumonia. Her level of consciousness decreased since the administration of cefepime, and she was diagnosed with NCSE based on electroencephalography (EEG) findings. After discontinuation of cefepime, improvement was seen both in the level of consciousness and EEG findings. Clinicians should be aware of cefepime-induced NCSE, particularly in patients with renal failure.

Keyword

Cefepime; Status epilepticus; Hemodialysis

MeSH Terms

Aged, 80 and over
Consciousness
Electroencephalography
Female
Humans
Pneumonia
Renal Dialysis*
Renal Insufficiency
Status Epilepticus*

Figure

• 

  Fig. 1 A brain magnetic resonance image revealed no structural lesions associated with the decreased consciousness.

• 

  Fig. 2 There were continuously generalized 2 Hz periodic epileptiform discharges. LOG, left oculogram; ROG, right oculogram; EKG, electrocardiogram.

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  Fig. 3 The background consisted of theta and delta rhythms which were symmetrically distributed without epileptiform features. LOG, left oculogram; ROG, right oculogram; EKG, electrocardiogram.

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