Ewha Med J.  2019 Jul;42(3):46-47. 10.12771/emj.2019.42.3.46.

Azathioprine-induced Myelodysplasia Mimicking Myelodysplastic Syndrome

• Ohe M

• KMID: 2454665
• DOI: http://doi.org/10.12771/emj.2019.42.3.46

Abstract

No abstract available.

MeSH Terms

Myelodysplastic Syndromes*

Figure

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  Fig. 1 The bone marrow aspiration smear reveals a neutrophil with hypersegmentation (Wright-Giemsa stain, ×1,000).

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  Fig. 2 (A) The bone marrow aspiration smear reveals an erythroblast with a bilobulated nucleus. (B) The bone marrow aspiration smear reveals an erythroblast with abundant cytoplasm and a multilobulated nucleus. (C) The bone marrow aspiration smear reveals an erythroblast with a multilobulated nucleus and Howell-Jolly bodies. (D) The bone marrow aspiration smear reveals an erythrocyte with abundant cytoplasm and Howell-Jolly bodies. (A–D) Wright-Giemsa stain, ×1,000.

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  Fig. 3 The bone marrow aspiration smear reveals a megakaryocyte with separated nuclei (Wright-Giemsa stain, ×1,000).

Reference

1. Kwong YL. Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia. J Rheumatol. 2010; 37:485–490.

2. Knipp S, Hildebrandt B, Richter J, Haas R, Germing U, Gattermann N. Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. Haematologica. 2005; 90:691–693.

3. Ahmad OF, Keane MG, McCartney S, Khwaja A, Bloom SL. Azathioprine-associated myelodysplastic syndrome in two patients with ulcerative colitis. Frontline Gastroenterol. 2013; 4:205–209.