Ann Dermatol.  1998 Oct;10(4):270-273. 10.5021/ad.1998.10.4.270.

Unusual Cutaneous Neutrophilic Infiltration in Myelodysplasia Syndrome : A Nuclear Segmentation Anomaly

• Kim SJ
• Seo JJ
• Lee SC
• Won YH

• KMID: 2359775
• DOI: http://doi.org/10.5021/ad.1998.10.4.270

Abstract

We report a case of myelodysplastic syndrome (MDS) with unique histopathological findings in which numerous infiltrated neutrophils exhibited nuclear segmentation anomalies. In comparison with well-described neutrophilic dermatoses of myelodysplastic syndrome such as Sweets syndrome and pyoderma gangrenosum, this case took a rapid and aggressive clinical course. We suggest that a nuclear segmentation anomaly, pseudo Pelger-Hiiet anomaly, is likely to reflect acute transformation of MDS and can be a poor prognostic marker.

Keyword

Myelodysplastic syndrome; Neutrophilic dermatoses; Nuclear segmentation anomaly; Acute transformation

MeSH Terms

Myelodysplastic Syndromes
Neutrophils*
Pyoderma Gangrenosum
Skin Diseases
Sweet Syndrome