Korean J Dermatol.  2015 Nov;53(9):722-725.

Neutrophilic Panniculitis in a Patient with Myelodysplastic Syndrome

• Lee HJ
• Kim GW
• Cho HH
• Kim WJ
• Mun JH
• Song M
• Kim HS
• Kim BS
• Kim MB
• Ko HC

Abstract

Myelodysplastic syndrome (MDS) is a heterogeneous group of stem cell disorders characterized by morphological abnormalities of the erythroid, granulocytic, and megakaryocytic cells. Cutaneous lesions associated with MDS are classified as either specific or non-specific. Specific leukemic infiltrates are often referred to as leukemia cutis, and non-specific inflammatory lesions, historically called leukemids, include cutaneous infections, vasculitis, and neutrophilic dermatoses. We report the case of a 53-year-old man who had been diagnosed with MDS 8 months ago when he developed multiple erythematous tender nodules on the trunk and upper extremities for 8 days. Histopathologic findings from an erythematous nodule on his chest showed lymphohistiocytic and neutrophilic infiltration in the septa and periphery of the fat lobules consistent with neutrophilic panniculitis. Most neutrophils observed in our case had the pseudo-Pelger-Huet anomaly. Herein we present a rare case of neutrophilic panniculitis associated with MDS showing specific groups and the pseudo-Pelger-Huet anomaly.

Keyword

Myelodysplastic syndrome; Neutrophilic panniculitis; Pseudo-Pelger-Huet anomaly; Subcutaneous Sweet syndrome

MeSH Terms

Humans
Leukemia
Middle Aged
Myelodysplastic Syndromes*
Neutrophils*
Panniculitis*
Skin Diseases
Stem Cells
Thorax
Upper Extremity
Vasculitis