Cancer Res Treat.  2016 Apr;48(2):605-611. 10.4143/crt.2015.092.

Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades

• Son IT
• Kim DW
• Jeong SY
• Shin YK
• Ihn MH
• Oh HK
• Kang SB
• Park KJ
• Oh JH
• Ku JL
• Park JG

• KMID: 2454338
• DOI: http://doi.org/10.4143/crt.2015.092

Abstract

PURPOSE
The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients.
MATERIALS AND METHODS
Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time.
RESULTS
The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly-period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001).
CONCLUSION
Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry's establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.

Keyword

Registration; Hereditary nonpolyposis colorectal neoplasms; Lynch syndrome

MeSH Terms

Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis*
Diagnosis
Humans
Korea
Neoplastic Syndromes, Hereditary
Registries
Retrospective Studies

Reference

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