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A Case of Lynch Syndrome with the Deletion of Multiple Exons of the MLH1 Gene, Detected by Next-Generation Sequencing

Hong J, Kim H, Hong YS, Lee W, Lim SB, Byeon JS, Chun S, Min WK

A 26-year-old man underwent colonoscopy to investigate weight loss and a lesion suspicious of colorectal cancer was detected. He had a family history of colorectal cancer and hepatocellular carcinoma. The...
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Lynch syndrome – Muir-Torre variant: implication in gynecologic oncology

Bogani G, Leone Roberti Maggiore U, Raspagliesi F

No abstract available.
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Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer

Takeda T, Tsuji K, Banno K, Yanokura M, Kobayashi , Tominaga E, Aoki D

OBJECTIVE: Lynch syndrome is a cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes. Lynch syndrome only causes about 0.4% of cases of ovarian cancer, which...
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Germline Variants in MLH1, MSH2, and MSH6 in Korean Patients with Lynch Syndrome

Park KJ, Chang DK, Kim HC, Kim JW

BACKGROUND: The phenotypic and genetic spectrum of Lynch syndrome (LS) seems to differ according to ethnicity. The aim of this study was to investigate the clinical, pathological, and genetic features...
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Hereditary Nonpolyposis Colorectal Cancer

Oh BY

Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common hereditary colorectal cancer syndrome and accounts for about 5% of colorectal cancer. It is inherited as autosomal dominant type and is...
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Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades

Son IT, Kim DW, Jeong SY, Shin YK, Ihn MH, Oh HK, Kang SB, Park KJ, Oh JH, Ku JL, Park JG

PURPOSE: The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study...
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Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome

Ahn DH, Rho JH, Tchah H, Jeon IS

Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of...
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Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum

Shin SH, Yu EJ, Lee YK, Song YS, Seong MW, Park SS

OBJECTIVE: The hereditary nonpolyposis colorectal cancer is inherited syndrome characterized by the development of cancers in various organ system; these includes colorectum, endometrium, and less frequently, small bowel, stomach, urinary...
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One case of endometrial cancer occurrence: Over 10 years after colon cancer in Lynch family

Lee JY, Kim HJ, Lee EH, Lee HW, Kim JW, Kim MK

We have recently experienced an endometrial cancer 12 years after the diagnosis of colon cancer with Lynch syndrome. A 49-year-old Korean woman had a family history of colon cancer. Her...
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CYCLIN D1 as a Genetic Modifier in Hereditary Nonpolyposis Colorectal Cancer

Kim WH

  • KMID: 1599443
  • Korean J Gastroenterol.
  • 2001 Nov;38(5):397-398.
No abstract available.
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Clinical Characteristics of Korean Hereditary Nonpolyposis Colorectal Cancer

Park YJ, Park KJ, Kang KJ, Kim KY, Kim S, Kim YJ, Kim CY, Kim JP, Kim JC, Oh NG

  • KMID: 2101314
  • J Korean Soc Coloproctol.
  • 1998 Mar;14(1):1-9.
Hereditary nonpolyposis colon cancer(HNPCC) accounts for 1~6% of colorectal cancer. Mutations in the DNA mismatch repair genes(hMSH2, hMLH1 and hPMS1, hPMS2 and hMSH6) are responsible for HNPCC. To evaluate the...
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Hereditary Nonpolyposis Colorectal Cancer

Gung HN, Lee SH, Hong SH, Yoon C, Lee KH

  • KMID: 2101291
  • J Korean Soc Coloproctol.
  • 1997 Sep;13(3):363-374.
Hereditary nonpolyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited disease associated with a marked increase in cancer susceptibility, especially cancer of the colorectum. The frequency of HNPCC in the general...
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Treatment of hereditary nonpolyposis colorectal cancer

Park JG, Seo JM, Han SU, Choe KJ, Kim JP, Jung HC, Song IS, Choi KW, Choi BI, Kim YI, Lee KH, Kim KY

  • KMID: 1685627
  • Korean J Gastroenterol.
  • 1993 Oct;25(5):892-902.
No abstract available.
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Clinical analysis of hereditary nonpolyposis colorectal cancer

Seo JM, Park JG, Choe KJ, Kim JP

  • KMID: 1686481
  • J Korean Soc Coloproctol.
  • 1992 Aug;8(2):111-119.
No abstract available.
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Hereditary nonpolyposis colorectal cancer: report of one case

Jung CH, Lee YC, Kim DK, Kim S, Choi WJ

  • KMID: 1686515
  • J Korean Soc Coloproctol.
  • 1992 Dec;8(3):297-302.
No abstract available.
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Hereditary nonpolyposis colorectal cancer: a case report

Kim JY, Kim HD, Kim KY

  • KMID: 1686513
  • J Korean Soc Coloproctol.
  • 1992 Dec;8(3):287-290.
No abstract available.
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Hereditary nonpolyposis colorectal cancer: report of one case

Seo JM, Park JG, Kim SJ, Kim JP

  • KMID: 1686429
  • J Korean Soc Coloproctol.
  • 1991 Dec;7(2):155-162.
No abstract available.
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