Perinatology.  2019 Jun;30(2):66-70. 10.14734/PN.2019.30.2.66.

Perinatal Outcomes of In Vitro Fertilization Versus Natural Pregnancy in Very Low Birth Weight Infants

  • 1Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
  • 2Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.


In vitro fertilization (IVF) pregnancy is increasing. The recent reviews have reported the perinatal outcomes of IVF were preterm birth, low birth weight, small for gestational age, congenital malformations, neurologic disorders and epigenetic defects. We aimed to analyze the perinatal outcomes of IVF compared with natural pregnancy on very low birth weight infants.
Our study population was derived from Neonatal Intensive Care Unit of the Gangnam CHA Medical Center from 2010 to 2014, consisting of singleton live births in very low birth weight infants. We grouped IVF group (n=24) and control group (natural pregnancy, n=112). We analyzed two groups about maternal characteristics, neonatal characteristics, and outcomes (retinopathy of prematurity [ROP], bronchopulmonary dysplasia [BPD], periventricular leukomalacia [PVL], necrotizing enterocolitis [NEC], death).
Maternal age was significantly older in IVF group (34.9±0.9 vs. 33.0±0.4, P=0.03). The Apgar score 1 minute of the IVF group was significantly lower than control group (4.0±0.3 vs. 4.8±0.2, P=0.03). But there were no other significant differences of neonatal morbidities. In univariate logistic regression analysis with IVF, the odds ratio of maternal age was 1.13 (95% confidence interval: 1.01-1.27, P=0.04). The relative risk of RDS, BPD, PVL, and ROP was increased, but it was not significant in univariate and multivariate logistic regression.
As the maternal age increased, IVF pregnancy was significantly higher. The relative risk of RDS, BPD, PVL, and ROP was high in IVF group, but it was not significant in univariate and multivariate logistic regression.


Infant; very low birth weight; Fertilization in vitro

MeSH Terms

Apgar Score
Bronchopulmonary Dysplasia
Enterocolitis, Necrotizing
Fertilization in Vitro*
Gestational Age
In Vitro Techniques*
Infant, Low Birth Weight
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care, Neonatal
Leukomalacia, Periventricular
Live Birth
Logistic Models
Maternal Age
Nervous System Diseases
Odds Ratio
Premature Birth
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