Investig Magn Reson Imaging.  2019 Jun;23(2):175-178. 10.13104/imri.2019.23.2.175.

A Case Report of Juvenile Hypertrophy of the Breast in a 15-Year-Old Girl: Presented with Asymmetric Breast Enlargement and a Focal Mass-like Lesion

• Park JY
• Kim SH
• Jung NY
• Kang BJ
• Lee AW
• Jin MS

• KMID: 2452534
• DOI: http://doi.org/10.13104/imri.2019.23.2.175

Abstract

Juvenile hypertrophy of the breast is a rare condition, leading to hyperplastic breast anomalies in adolescents. Here, we report a case involving a 15-year-old girl, presented with asymmetric enlargement of the left breast. Pronounced parenchymal thickening was found on initial ultrasonography (US). MRI and second-look US revealed a focal mass-like lesion on the left mid-lateral breast, confirmed as juvenile hypertrophy of the breast on pathology.

Keyword

Breast; Ultrasonography; Magnetic Resonance Imaging; Hypertrophy; Gigantomastia

MeSH Terms

Adolescent*
Breast*
Female*
Humans
Hypertrophy*
Magnetic Resonance Imaging
Pathology
Ultrasonography

Figure

• 

  Fig. 1. 15-year-old girl with juvenile hypertrophy of the left breast. (a) Posteroanterior chest radiograph shows enlargement of left breast shadow (arrows), compared with the right one. A chest radiograph from 7 years ago (not shown), shows no asymmetry or soft tissue masses on the left chest. (b) Initial ultrasonography (US) images shows pronounced parenchymal thickening of the left breast, compared to the right breast (not shown). (c) Axial T2-weighted magnetic resonance (MR) image shows the enlarged left breast exhibiting diffuse high signal intensity, compared to right breast as well as a small oval mass (arrows) at the mid-lateral portion of the left breast, showing slightly higher signal intensity than the opposite normal breast parenchyma. (d) Axial T1-weighted MR image shows the enlarged left breast and a mass at the mid-lateral portion of the left breast (arrows), showing isointensity compared to the right breast parenchyma. (e) On axial contrast-enhanced T1-weighted MR image, the enlarged left breast exhibits slightly prominent background parenchymal enhancement, as well as a mass at the mid-lateral portion of the left breast (arrows), showing mild homogeneous enhancement. (f) Time intensity curves of dynamic contrast enhancement, with placement of regions of interest on the enhancing mass, are initial medium and delayed persistent patterns. (g) Second-look US after MR image revealed an approximately 2.2 cm circumscribed oval hypoechoic lesion at the mid-lateral portion of the left breast. (h) Low-power view (Hematoxylin & Eosin stain, × 40) of breast tissue from the mass on the left breast shows small duct proliferation, with periductal stromal fibrosis and focal inconspicuous lobules. (i) On high-power view (Hematoxylin & Eosin stain, × 200), involved ducts exhibit epithelial hyperplasia with formation of small, abortive, short, and tapering micropapillae.

Reference

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