Ann Pediatr Endocrinol Metab.  2014 Mar;19(1):45-48. 10.6065/apem.2014.19.1.45.

Giant juvenile fibroadenoma of the breast: a case report and brief literature review

• Song BS
• Kim EK
• Seol H
• Seo JH
• Lee JA
• Kim DH
• Lim JS

• KMID: 1702664
• DOI: http://doi.org/10.6065/apem.2014.19.1.45

Abstract

A girl (age, 12 years 11 months) consulted the pediatric endocrinology clinic because of a rapidly growing right breast mass over 13 cm observed during the preceding 3 months. A surgical excision was performed, and the mass was diagnosed as a giant juvenile fibroadenoma. Giant juvenile fibroadenomas are rare, usually occurring between 10 and 18 years of age, and characterized by massive and rapid enlargement of an encapsulated mass. The etiology is believed to be an end-organ hypersensitivity to normal levels of estrogen. We report a case of giant juvenile fibroadenoma and present a review of the diagnostic workup and management of a large breast tumor during adolescence.

Keyword

Juvenile gigantomastia; Fibroadenoma; Breast; Adolescent

MeSH Terms

Adolescent
Breast Neoplasms
Breast*
Endocrinology
Estrogens
Female
Fibroadenoma*
Humans
Hypersensitivity
Estrogens

Figure

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  Fig. 1 Gross appearance of the right breast. The overlying skin has a shiny, tense appearance with vein engorgement.

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  Fig. 2 An ultrasonogram showing a well capsulated giant homogeneous isoechoic mass occupying entire right breast.

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  Fig. 3 The tumor is covered with a capsule and is elastic hard. The cut surface is solid and has a yellowish white tan color.

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  Fig. 4 The tumor shows pericanalicular pattern growth, uniformly increased stromal cellularity, and epithelial proliferation (H&E, ×40).

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