Korean J Intern Med.
2019 Jan;34(1):195-201. 10.3904/kjim.2015.365.
Direct costs of severe cutaneous adverse reactions in a tertiary hospital in Korea
- Affiliations
-
- 1Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
- 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. helenmed@snu.ac.kr
- 3Drug Safety Monitoring Center, Seoul National University Hospital, Seoul, Korea.
- 4Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
- 5Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
- 6Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
- KMID: 2452503
- DOI: http://doi.org/10.3904/kjim.2015.365
Abstract
- BACKGROUND/AIMS
There are only a few reports on the direct costs of severe cutaneous adverse reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), despite the tremendous negative impact these reactions can have on patients. We estimated the direct costs of treating SCARs.
METHODS
Patients admitted to a tertiary teaching hospital for the treatment of SCARs from January 1, 2005 to December 31, 2010 were included. Patients who had experienced SCARs during their admission for other medical conditions were excluded. The direct costs of hospitalization and outpatient department visits were collected. Inpatient and outpatient care costs were calculated, and factors affecting inpatient care costs were analyzed.
RESULTS
The total healthcare cost for the management of 73 SCAR patients (36 with DRESS, 21 with SJS, and 16 with TEN) was 752,067 US dollars (USD). Most of the costs were spent on inpatient care (703,832 USD). The median inpatient care cost per person was 3,720 (range, 1,133 to 107,490) USD for DRESS, 4,457 (range, 1,224 to 21,428) USD for SJS, and 8,061 (range, 1,127 to 52,220) USD for TEN. Longer hospitalization significantly increased the inpatient care costs of the patients with DRESS (by 428 USD [range, 395 to 461] per day). Longer hospitalization and death significantly increased the inpatient care costs of the patients with SJS/TEN (179 USD [range, 148 to 210] per day and an additional 14,425 USD [range, 9,513 to 19,337] for the deceased).
CONCLUSIONS
The management of SCARs required considerable direct medical costs. SCARs are not only a health problem but also a significant financial burden for the affected individuals.
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