Psychiatry Investig.  2019 Jun;16(6):459-463. 10.30773/pi.2019.03.10.

Clinical Characteristics and Psychotropic Drug Prescription Patterns of Bipolar Disorder Patients with a History of Suicidal Attempts: Findings from the REAP-BD, Korea

  • 1Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.
  • 2Department of Psychiatry, Veteran Health Service Medical Center, Seoul, Republic of Korea.
  • 3Department of Psychiatry, Bugok National Hospital, Changyeong, Republic of Korea.
  • 4Department of Psychiatry, Chosun University Hosptial, Gwangju, Republic of Korea.
  • 5Department of Psychiatry, Jeju National University, Jeju, Republic of Korea.
  • 6Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea.
  • 7Department of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.
  • 8Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
  • 9Department of Pharmacology, National University Hospital, Singapore, Singapore.
  • 10Department of Social Welfare, School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan.


Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar disorder. The patterns of clinical characteristics and psychotropic drug use were compared among 53 patients with a history of suicide attempts and 297 without this history; the potential effects of confounding variables were adjusted with binary logistic analyses for discrete variables and analyses of covariance for continuous variables. After adjusting the effects of age, sex, duration of illness, and enrollment as an outpatient, patients with a history of suicide attempts were characterized by a significantly more prevalent depressive episode, lower prevalent remission state, lower levels of hemoglobin, and more use of antidepressants, anxiolytics, and hypnotics compared to those without lifetime suicide attempt. The inability to plan goal-directed behavior may be an intervening factor in the relationship between suicide attempts and depression in BD. Relatively low hemoglobin levels can be associated with manic episodes in patients with a history of suicide attempts and the use of antidepressants, anxiolytics, or hypnotics can be associated with suicide attempts in BD patients.


Antidepressant; Bipolar disorder; Depressive episode; Hemoglobin; Suicide attempt

MeSH Terms

Anti-Anxiety Agents
Antidepressive Agents
Asian Continental Ancestry Group
Bipolar Disorder*
Confounding Factors (Epidemiology)
Drug Prescriptions*
Hypnotics and Sedatives
Anti-Anxiety Agents
Antidepressive Agents
Hypnotics and Sedatives
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