Obstet Gynecol Sci.  2019 Jul;62(4):233-241. 10.5468/ogs.2019.62.4.233.

Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

• Cho GJ
• Jung US
• Sim JY
• Lee YJ
• Bae NY
• Choi HJ
• Park JH
• Kim HJ
• Oh MJ

• KMID: 2451652
• DOI: http://doi.org/10.5468/ogs.2019.62.4.233

Abstract

OBJECTIVE
This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status.
METHODS
Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery.
RESULTS
Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P<0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05-1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome.
CONCLUSION
In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period.

Keyword

Preeclampsia; Metabolic syndrome; Cardiovascular disease; Diabetes mellitus; Hypertension

MeSH Terms

Blood Pressure
Body Mass Index
Cardiovascular Diseases
Child
Cholesterol
Diabetes Mellitus
Female
Humans
Hypertension
Lipoproteins
Mass Screening
National Health Programs
Postpartum Period
Pre-Eclampsia*
Prevalence
Risk Factors*
Triglycerides
Waist Circumference
Cholesterol
Lipoproteins

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