J Korean Med Sci.  2018 Feb;33(6):e35. 10.3346/jkms.2018.33.e35.

Preeclampsia Increases the Incidence of Postpartum Cerebrovascular Disease in Korean Population

• Park Y
• Cho GJ
• Kim LY
• Lee TS
• Oh MJ
• Kim YH

• KMID: 2450459
• DOI: http://doi.org/10.3346/jkms.2018.33.e35

Abstract

BACKGROUND
Multiple studies have been reported regarding preeclampsia as a possible risk factor of cerebrovascular disease (CVD). However, the correlation of preeclampsia and CVD, whether it is a cause-effect relationship or they are sharing common predisposing condition, is not well understood. Therefore, the aim of this study was to investigate the association between the preeclampsia during pregnancy and development of postpartum CVD.
METHODS
A total of 1,384,550 Korean women who had a delivery between January 1, 2010 and December 31, 2012, were enrolled. Women with the risk of CVD within 1 year prior to pregnancy were excluded based on the Charlson comorbidity index. Primary endpoint was the event of CVD within a year from delivery. After exclusion, 1,075,061 women were analyzed.
RESULTS
During the follow-up of 1 year postpartum, there were 25,577 preeclampsia out of 1,072,041 women without postpartum CVD (2.39%), and 121 of 3,020 women with postpartum CVD had preeclampsia before delivery (4.01%). In multivariate logistic regression analysis, women who had preeclampsia during pregnancy showed a higher risk for postpartum CVD (odds ratio, 1.64; 95% confidence interval, 1.37-1.98).
CONCLUSION
The incidence of CVD after delivery was higher in women who had preeclampsia during pregnancy.

Keyword

Cerebrovascular Disease; Pregnancy; Postpartum Period; Preeclampsia; Insurance Claim Reporting; Korea

MeSH Terms

Cerebrovascular Disorders*
Comorbidity
Female
Follow-Up Studies
Humans
Incidence*
Insurance Claim Reporting
Korea
Logistic Models
Postpartum Period*
Pre-Eclampsia*
Pregnancy
Risk Factors