J Clin Neurol.  2019 Jul;15(3):415-417. 10.3988/jcn.2019.15.3.415.

Intravascular lymphoma as a Potential Cause of Recurrent Embolic Stroke of Undetermined Source

• Woo KA
• Yoo D
• Jung KH

• KMID: 2451133
• DOI: http://doi.org/10.3988/jcn.2019.15.3.415

Abstract

No abstract available.

MeSH Terms

Lymphoma*
Stroke*

Figure

• 

  Fig. 1 Brain MRI and systemic radiological features of patients 1 and 2. A–E: Serial brain diffusion-weighted MRI sequences of patient 1 (A, B) and patient 2 (C–E) performed after each episode of acute neurological deterioration. The images revealed multifocal diffusion-restricted lesions with low apparent diffusion coefficient values suggesting acute infarctions (red arrowheads) in the bilateral cerebral hemispheres. In patient 2, CT of the abdomen (F) revealed renal and splenic infarctions (arrows). T1-enhanced MRI of the brain (G) revealed prominent leptomeningeal enhancement in bilateral parieto-occipital regions and nodular enhanced lesions around the fourth ventricle (arrows).

Reference

1. Hart RG, Catanese L, Perera KS, Ntaios G, Connolly SJ. Embolic stroke of undetermined source: a systematic review and clinical update. Stroke. 2017; 48:867–872.

2. Fonkem E, Dayawansa S, Stroberg E, Lok E, Bricker PC, Kirmani B, et al. Neurological presentations of intravascular lymphoma (IVL): metaanalysis of 654 patients. BMC Neurol. 2016; 16:9.

3. Kim JM, Jung KH, Lee ST, Park HK, Chu K, Roh JK. Stroke mimicking encephalopathy as an initial manifestation of diffuse large B-cell lymphoma. J Clin Neurol. 2009; 5:97–100.

4. Cestari DM, Weine DM, Panageas KS, Segal AZ, DeAngelis LM. Stroke in patients with cancer: incidence and etiology. Neurology. 2004; 62:2025–2030.

5. Bick RL. Cancer-associated thrombosis. N Engl J Med. 2003; 349:109–111.

6. Zuckerman D, Seliem R, Hochberg E. Intravascular lymphoma: the oncologist's “great imitator”. Oncologist. 2006; 11:496–502.

7. Fonkem E, Lok E, Robison D, Gautam S, Wong ET. The natural history of intravascular lymphomatosis. Cancer Med. 2014; 3:1010–1024.

8. Shimada K, Kinoshita T, Naoe T, Nakamura S. Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol. 2009; 10:895–902.

9. Baehring JM, Longtine J, Hochberg FH. A new approach to the diagnosis and treatment of intravascular lymphoma. J Neurooncol. 2003; 61:237–248.