Blood Res.  2018 Jun;53(2):177-180. 10.5045/br.2018.53.2.177.

Acetate moderately attenuates the generation of neutrophil extracellular traps

• Ohbuchi A
• Kono M
• Takenokuchi M
• Imoto S
• Saigo K

• KMID: 2451042
• DOI: http://doi.org/10.5045/br.2018.53.2.177

Abstract

No abstract available.

MeSH Terms

Extracellular Traps*
Neutrophils*

Figure

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  Fig. 1 Effects of short-chain fatty acids on NET generation and reactive oxygen species production. A quantitative analysis revealed that acetate had a dose-dependent inhibitory activity on NETs generation, although its potency was lower than that of DPI.

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  Fig. 2 Morphological observation by fluorescence microscopy. SYTOX Green staining revealed the ability of acetate to inhibit NETs. (A, E, I) Control; (B, F, J) 25 mM acetate alone; (C, G, K) 50 nM PMA alone; (D, H, L) 50 nM PMA with 25 mM acetate. (A-D, SYTOX Green staining) (E-H, SYTO 59 Red staining) (I-L, phase-contrast micrographs, ×100).

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