J Korean Med Sci.  2019 Jun;34(24):e171. 10.3346/jkms.2019.34.e171.

Associations between the HaeIII Single Nucleotide Polymorphism in the SLC2A1 Gene and Diabetic Nephropathy in Korean Patients with Type 2 Diabetes Mellitus

• Lee DH
• Won GW
• Lee YH
• Ku EJ
• Oh TK
• Jeon HJ

• KMID: 2449986
• DOI: http://doi.org/10.3346/jkms.2019.34.e171

Abstract

BACKGROUND
Diabetic nephropathy (DN) is the most serious microvascular complication of diabetes mellitus and is one of the leading causes of end stage renal failure. In previous studies, the contribution of genetic susceptibility to DN showed inconsistent results. In this study, we investigated the association between the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) HaeIII polymorphism and DN in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.
METHODS
A total of 846 patients with T2DM (mean age, 61.3 ± 12.3 years; mean duration of T2DM, 10.3 ± 7.9 years; 55.3% men) who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of the SLC2A1 gene was determined by the real time polymerase chain reaction method. Genotyping results were presented as GG, AG, or AA. A subgroup analysis was performed according to duration of T2DM (≤ 10 years, < 10 years).
RESULTS
The AG + AA genotype showed a significantly higher risk of DN compared with the GG genotype in patients with a type 2 DM duration less than 10 years (12.4% vs. 4.2%; P < 0.001). No significant differences were observed in terms of other diabetic complications, including retinopathy, peripheral neuropathy, cardiovascular disease, cerebrovascular disease or peripheral artery disease, according to the genotypes of the SLC2A1 HaeIII polymorphism.
CONCLUSION
The SLC2A1 HaeIII polymorphism was associated with DN in Korean patients with T2DM, particularly in the group with a relatively short disease duration.

Keyword

Polymorphism; SLC2A1; HaeIII; Diabetic Nephropathies; Diabetes Mellitus, Type 2

MeSH Terms

Cardiovascular Diseases
Cerebrovascular Disorders
Chungcheongbuk-do
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Type 2*
Diabetic Nephropathies*
Genetic Predisposition to Disease
Genotype
Glucose Transport Proteins, Facilitative
Humans
Methods
Peripheral Arterial Disease
Peripheral Nervous System Diseases
Polymorphism, Single Nucleotide*
Real-Time Polymerase Chain Reaction
Renal Insufficiency
Glucose Transport Proteins, Facilitative