Korean J Dermatol.  2019 May;57(4):194-196.

Multiple Eruptive Dermatofibromas in a Patient with Myasthenia Gravis Treated with Systemic Corticosteroid

• Park GH
• Kim T
• Park S
• Lee HJ
• Jin H
• Shim WH
• Kim GW
• Kim HS
• Ko HC
• Kim BS
• Kim MB
• You HS

Abstract

Dermatofibroma is a fibrohistiocytic tumor of the skin that commonly occurs as a solitary lesion on the lower extremities of young women. Multiple eruptive dermatofibromas (MEDFs), defined as the presence of 5 to 8 dermatofibromas appearing within a period of 4 months, are rare, and the etiology of MEDFs remains unknown. However, MEDFs are frequently thought to be associated with altered immunity, such as autoimmune diseases and immunosuppression. It is unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein describe a middle-aged woman who developed multiple dermatofibroma. She had myasthenia gravis for 8 years, and developed MEDFs after undergoing oral corticosteroid treatment (245 mg/week) for 3 months. Therefore, our case suggests that the use of immunosuppressants is a more dominant factor for the development of MEDFs than underlying autoimmune diseases.

Keyword

Multiple eruptive dermatofibromas; Myasthenia gravis; Immunosuppression

MeSH Terms

Autoimmune Diseases
Female
Histiocytoma, Benign Fibrous*
Humans
Immunosuppression
Immunosuppressive Agents
Lower Extremity
Myasthenia Gravis*
Skin
Immunosuppressive Agents