Korean J Fam Med.  2019 May;40(3):176-181. 10.4082/kjfm.18.0139.

The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes

• Choi JI
• Cho YH
• Lee SY
• Jeong DW
• Lee JG
• Yi YH
• Tak YJ
• Lee SH
• Hwang HR
• Park EJ

• KMID: 2449016
• DOI: http://doi.org/10.4082/kjfm.18.0139

Abstract

BACKGROUND
The prevalence of chronic kidney disease is increasing worldwide. Several studies have suggested that obesity is associated with early renal dysfunction. However, little is known about the relationship between obesity phenotypes and early renal function decline. Therefore, this study aimed to identify the relationship between obesity phenotypes and early renal function decline in adults without hypertension, dyslipidemia, and diabetes.
METHODS
We conducted a cross-sectional analysis of clinical and anthropometric data from 1,219 patients who underwent a routine health checkup in 2014. We excluded adults with cardiovascular disease, renal disease, diabetes, hypertension, dyslipidemia, or low glomerular filtration rate (<60 mL/min/1.73 m2). Renal function was determined according to the estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation.
RESULTS
Age, sex, body mass index, waist circumference, triglyceride, low-density lipoprotein, and fasting glucose had an association with the estimated glomerular filtration rate. After adjusting for age, sex, smoking status, and alcohol intake, the odds ratios of the metabolically abnormal normal weight and metabolically abnormal obese phenotypes for the presence of low estimated glomerular filtration rates were 1.807 (95% confidence interval, 1.009-3.236) and 1.834 (95% confidence interval, 1.162-2.895), compared with the metabolically healthy normal weight phenotype. However, the metabolically healthy obese phenotype did not show a significant association with early renal function decline.
CONCLUSION
In this cross-sectional study, we confirmed the association between the metabolically abnormal normal weight and metabolically abnormal obese phenotypes and early kidney function decline in adults without hypertension, dyslipidemia, and diabetes.

Keyword

Obesity; Metabolic Syndrome; Kidney Function Tests; Glomerular Filtration Rate

MeSH Terms

Adult*
Body Mass Index
Cardiovascular Diseases
Cooperative Behavior
Cross-Sectional Studies
Dyslipidemias*
Epidemiology
Fasting
Glomerular Filtration Rate
Glucose
Humans
Hypertension*
Kidney
Kidney Function Tests
Lipoproteins
Obesity*
Odds Ratio
Phenotype*
Prevalence
Renal Insufficiency, Chronic
Smoke
Smoking
Triglycerides
Waist Circumference
Glucose
Lipoproteins
Smoke