J Vet Sci.  2019 May;20(3):e12. 10.4142/jvs.2019.20.e12.

Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel

• San R
• Yue W
• Hasi S

• KMID: 2448701
• DOI: http://doi.org/10.4142/jvs.2019.20.e12

Abstract

The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen only or with the enzyme inhibitor lomefloxacin. Blood samples were collected after different intervals, and p-acetaminophen concentration was determined by high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by Phoenix WinNonLin v.7.0. The results show that lomefloxacin can significantly inhibit Bactrian camel CYP1A enzyme, as evidenced by the prolonged elimination half-life, increased maximum plasma concentration and area under the curve values and the shortened time to peak concentration for p-acetaminophenol in the substrate with inhibitor group. The results lay a foundation for revealing the particular characteristics of the CYP1A enzyme in Bactrian camels.

Keyword

Bactrian camel; CYP1A; substrate; pharmacokinetics; inhibitor

MeSH Terms

Camels*
Chromatography, Liquid
Half-Life
Pharmacokinetics*
Plasma