J Lipid Atheroscler.  2019 May;8(1):1-7. 10.12997/jla.2019.8.1.1.

Intermittent Fasting: a Promising Approach for Preventing Vascular Dementia

• Yoon G
• Song J

• KMID: 2447751
• DOI: http://doi.org/10.12997/jla.2019.8.1.1

Abstract

Vascular dementia is the most common neuropsychiatric syndrome and is characterized by synaptic dysfunction, neuroinflammation, and cognitive dysfunction. Vascular dementia is associated with various environmental, genetic, and lifestyle risk factors. Recent research has focused on the association between vascular dementia and dietary patterns, suggesting that dietary regulation leads to better control of energy metabolism, improvements in brain insulin resistance, and the suppression of neuroinflammation. Intermittent fasting is a calorie-restriction method known to be more effective in promoting fat loss and regulating the impairment of glucose metabolism as compared with other dietary restriction regimens. Herein, the authors review the effects of intermittent fasting with regard to vascular dementia based on recent evidence and propose that intermittent fasting could be a therapeutic approach for ameliorating vascular dementia pathology and preventing its onset.

Keyword

Intermittent fasting; Vascular dementia; Cognitive function

MeSH Terms

Brain
Cognition
Dementia, Vascular*
Energy Metabolism
Fasting*
Glucose
Insulin Resistance
Life Style
Metabolism
Methods
Pathology
Risk Factors
Glucose

Figure

• 

  Fig. 1 The positive effects of intermittent fasting in dementia. Pathologies in dementia including neuroinflammation, the abnormal secretion of neurotransmitters, synaptic dysfunction, cerebrovascular inflammation, brain insulin resistance, and impaired neurogenesis were improved by intermittent fasting.

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