Korean J Med Mycol.  2019 Mar;24(1):1-8. 10.17966/JMI.2019.24.1.1.

Clinical and Biochemical Assessment of New-formula Shampoo for Scalp Seborrheic Dermatitis

• Kim JH
• Kim JH
• Shin HJ
• Lee YW

• KMID: 2447745
• DOI: http://doi.org/10.17966/JMI.2019.24.1.1

Abstract

BACKGROUND
Scalp seborrheic dermatitis is a common disease characterized by flaking and itching of the scalp. Conventional treatment options, such as the use of topical corticosteroids and antifungal agents, may cause adverse effects and reduce user satisfaction rates; thus, it is important to explore other treatment options for scalp seborrheic dermatitis.
OBJECTIVE
We aimed to evaluate the efficacy and safety of a new-formula shampoo containing natural ingredients, including the extract of Rosa centifolia petals, epigallocatechin gallate, zinc pyrithione, and climbazole.
METHODS
A total of 50 patients with scalp seborrheic dermatitis were enrolled and divided into two groups: the new-formula shampoo-treated group and the 1.5% ciclopirox olamine shampoo-treated group. Clinical severity scores, sebum secretion, and inflammatory cytokines were assessed. In addition, patient satisfaction and adverse events were assessed using a questionnaire.
RESULTS
The new-formula shampoo was comparable with ciclopirox in reducing the clinical severity scores and sebum secretion. Patients' improvement scores and user satisfaction rates were higher in the new-formula shampoo group than in the 1.5% ciclopirox olamine shampoo-treated group. The inflammatory cytokine levels considerably changed in both groups during the course of the study.
CONCLUSION
Thus, the new-formula shampoo can be considered a treatment option for patients with scalp seborrheic dermatitis.

Keyword

Malassezia; New-formula shampoo; Scalp; Seborrheic dermatitis

MeSH Terms

Adrenal Cortex Hormones
Antifungal Agents
Cytokines
Dermatitis, Seborrheic*
Humans
Malassezia
Patient Satisfaction
Pruritus
Rosa
Scalp*
Sebum
Zinc
Adrenal Cortex Hormones
Antifungal Agents
Cytokines
Zinc