Ann Dermatol.  2014 Dec;26(6):733-738. 10.5021/ad.2014.26.6.733.

Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study

• Kim YR
• Kim JH
• Shin HJ
• Choe YB
• Ahn KJ
• Lee YW

• KMID: 2264869
• DOI: http://doi.org/10.5021/ad.2014.26.6.733

Abstract

BACKGROUND
Scalp seborrheic dermatitis is a chronic type of inflammatory dermatosis that is associated with sebum secretion and proliferation of Malassezia species. Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options.
OBJECTIVE
This study was designed to evaluate a new-formula shampoo that contains natural ingredients-including extract of Rosa centifolia petals and epigallocatechin gallate (EGCG)-that exert antioxidative, anti-inflammatory, and sebum secretion inhibitory effects, and antifungal agents for the treatment of scalp seborrheic dermatitis.
METHODS
Seventy-five patients were randomized into three treatment groups; new-formula shampoo, 2% ketoconazole shampoo, and 1% zinc- pyrithione shampoo. The clinical severity scores and sebum levels were assessed by the same dermatologists at baseline (week 0), and at 2 and 4 weeks after using the shampoo. User satisfaction and irritation were also assessed with the aid of a questionnaire.
RESULTS
The efficacy of the new-formula shampoo was comparable to that of both the 1% zinc-pyrithione shampoo and the 2% ketoconazole shampoo. Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared with the 2% ketoconazole shampoo. However, the new-formula shampoo did not exhibit the previously reported sebum inhibitory effect.
CONCLUSION
Extract of R. centifolia petals or EGCG could be useful ingredients in the treatment of scalp seborrheic dermatitis.

Keyword

Ellagitannins; Epigallocatechin gallate; Ketoconazole; Seborrheic dermatitis; Zinc pyrithione

MeSH Terms

Antifungal Agents
Dermatitis, Seborrheic*
Erythema
Humans
Hydrolyzable Tannins
Ketoconazole
Malassezia
Rosa*
Scalp*
Sebum
Skin Diseases
Surveys and Questionnaires
Antifungal Agents
Hydrolyzable Tannins
Ketoconazole

Figure

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  Fig. 1 Change in clinical severity score. Values are mean±standard error.

• 

  Fig. 2 Change in sebum secretion.

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