Arch Craniofac Surg.  2019 Apr;20(2):121-125. 10.7181/acfs.2018.02089.

Upper eyelid Merkel cell carcinoma treated with neoadjuvant chemotherapy and surgical excision

Affiliations
  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University, Rome, Italy. m.alessandribonetti@gmail.com
  • 2Department of Oncology, Campus Bio-Medico di Roma University, Rome, Italy.
  • 3Department of Dermatology and Venereology, Sapienza University, Rome, Italy.

Abstract

Merkel cell carcinoma is a rare cutaneous carcinoma, featured by an aggressive clinical course and a mortality rate of 28% at 2 years. A 71-year-old female was affected by a 4.1-cm-wide locally advanced Merkel cell carcinoma of the upper eyelid, previously misdiagnosed as chalazion, with involvement of the extraocular muscles. Although the tumor showed a macroscopic spontaneous regression in size after the incisional biopsy, the mass was treated with neoadjuvant chemotherapy and surgical excision. Good functional and aesthetic result with preservation of the eyeball and absence of tumor recurrence were achieved at 3-year follow-up. In our experience, the combination of the inflammatory cascade due to the incisional biopsy and neoadjuvant chemotherapy led to the regression of a locally advanced large Merkel cell carcinoma of the eyelid.

Keyword

Carcinoma; Chalazion; Eyelid neoplasm; Merkel cell; Neoadjuvant therapy; Skin neoplasm

MeSH Terms

Aged
Biopsy
Carcinoma, Merkel Cell*
Chalazion
Drug Therapy*
Eyelid Neoplasms
Eyelids*
Female
Follow-Up Studies
Humans
Mortality
Muscles
Neoadjuvant Therapy
Recurrence
Skin Neoplasms
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