Clin Exp Emerg Med.  2019 Mar;6(1):25-30. 10.15441/ceem.17.275.

Pilot study on a rewarming rate of 0.15°C/hr versus 0.25°C/hr and outcomes in post cardiac arrest patients

Affiliations
  • 1Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea. mutjeo@gmail.com

Abstract


OBJECTIVE
Cerebral hemodynamic and metabolic changes may occur during the rewarming phase of targeted temperature management in post cardiac arrest patients. Yet, studies on different rewarming rates and patient outcomes are limited. This study aimed to investigate post cardiac arrest patients who were rewarmed with different rewarming rates after 24 hours of hypothermia and the association of these rates to the neurologic outcomes.
METHODS
This study retrospectively investigated post cardiac arrest patients treated with targeted temperature management and rewarmed with rewarming rates of 0.15°C/hr and 0.25°C/hr. The association of the rewarming rate with poor neurologic outcomes (cerebral performance category score, 3 to 5) was investigated.
RESULTS
A total of 71 patients were analyzed (0.15°C/hr, n=36; 0.25°C/hr, n=35). In the comparison between 0.15°C/hr and 0.25°C/hr, the poor neurologic outcome did not significantly differ (24 [66.7%] vs. 25 [71.4%], respectively; P=0.66). In the multivariate analysis, the rewarming rate of 0.15°C/hr was not associated with the 1-month neurologic outcome improvement (odds ratio, 0.54; 95% confidence interval, 0.16 to 1.69; P=0.28).
CONCLUSION
The rewarming rates of 0.15°C/hr and 0.25°C/hr were not associated with the neurologic outcome difference in post cardiac arrest patients.

Keyword

Rewarming; Heart arrest; Critical care outcomes

MeSH Terms

Critical Care Outcomes
Heart Arrest*
Hemodynamics
Humans
Hypothermia
Multivariate Analysis
Pilot Projects*
Retrospective Studies
Rewarming*
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