Kidney Res Clin Pract.  2018 Sep;37(3):292-297. 10.23876/j.krcp.2018.37.3.292.

Use of dapagliflozin in patients with advanced diabetic kidney disease

• Park HS
• Jung YJ
• Lee DY
• Moon KH
• Kim B
• Kim HW

• KMID: 2447169
• DOI: http://doi.org/10.23876/j.krcp.2018.37.3.292

Abstract

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective for overweight diabetic patients through the induction of glucosuria. However, SGLT2 inhibitors are not recommended for patients with advanced chronic kidney disease (CKD) because they may aggravate renal function and thus become less effective in controlling blood glucose in this patient population. We suggest that adequate hydration would be helpful to prevent the side effects of SGLT2 inhibitors in diabetic patients with advanced CKD. In this study, we review five cases of SGLT2 inhibitor therapy, specifically with dapagliflozin, for the treatment of diabetes mellitus in patients with advanced CKD. The patients experienced dramatic weight reduction, improved glucose control, and further benefits without aggravation of renal function.

Keyword

Albuminuria; Chronic kidney disease; Dapagliflozin; Hyperuricemia; Obesity

MeSH Terms

Albuminuria
Blood Glucose
Diabetes Mellitus
Diabetic Nephropathies*
Glucose
Humans
Hyperuricemia
Obesity
Overweight
Renal Insufficiency, Chronic
Weight Loss
Blood Glucose
Glucose