Kidney Res Clin Pract.  2018 Sep;37(3):287-291. 10.23876/j.krcp.2018.37.3.287.

Dihydroxyadenine crystal-induced nephropathy presenting with rapidly progressive renal failure

Affiliations
  • 1Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. dr_rituverma@rediffmail.com

Abstract

Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis. Herein, we report a young female with dihydroxyadenine (DHA) crystal-induced nephropathy presenting with rapidly progressive renal failure. DHA crystals can be easily diagnosed by their pathognomic color and shape in urine and biopsy specimens. A high index of clinical suspicion helps in the early diagnosis of this potentially treatable renal disease.

Keyword

Adenine phosphoribosyltransferase; Crystal nephropathy; Dihydroxyadenine crystals

MeSH Terms

Adenine Phosphoribosyltransferase
Biopsy
Early Diagnosis
Female
Humans
Renal Insufficiency*
Urolithiasis
Adenine Phosphoribosyltransferase
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