Kidney Res Clin Pract.  2018 Sep;37(3):287-291. 10.23876/j.krcp.2018.37.3.287.

Dihydroxyadenine crystal-induced nephropathy presenting with rapidly progressive renal failure

• Verma R
• Niraimathi M
• Prasad P
• Agrawal V

• KMID: 2447168
• DOI: http://doi.org/10.23876/j.krcp.2018.37.3.287

Abstract

Adenine phosphoribosyltransferase enzyme deficiency is a rare, autosomal recessive disorder. It is a disease limited to the renal system and usually presents with urolithiasis. Herein, we report a young female with dihydroxyadenine (DHA) crystal-induced nephropathy presenting with rapidly progressive renal failure. DHA crystals can be easily diagnosed by their pathognomic color and shape in urine and biopsy specimens. A high index of clinical suspicion helps in the early diagnosis of this potentially treatable renal disease.

Keyword

Adenine phosphoribosyltransferase; Crystal nephropathy; Dihydroxyadenine crystals

MeSH Terms

Adenine Phosphoribosyltransferase
Biopsy
Early Diagnosis
Female
Humans
Renal Insufficiency*
Urolithiasis
Adenine Phosphoribosyltransferase