J Korean Med Sci.  1992 Sep;7(3):264-270. 10.3346/jkms.1992.7.3.264.

'Pauci-immune' rapidly progressive glomerulonephritis associated with systemic vasculitis

• Han JY
• Yoon SA
• Woo JY
• Park IS
• Kim SY
• Chang YS
• Bang BK

• KMID: 1421923
• DOI: http://doi.org/10.3346/jkms.1992.7.3.264

Abstract

'Pauci-immune' glomerulonephritis has been recognized as an important cause of rapidly progressive glomerulonephritis. The paucity of immune deposits can be separated from the other two major immunohistologic variants of crescentic glomerulonephritis, ie, antiglomerular basement membrane (GBM) antibody-mediated and immune complex-mediated glomerulonephritis. Here we describe the case of a 42-year-old woman with pauci-immune' glomerulonephritis and vasculitis presenting as rapidly progressive renal failure with characteristic pathologic and immunohistologic findings. And in this case, despite oliguria and rapid deterioration of renal function, the renal function recovered partially and continued to be stabilized with a favourable response to hemodialysis and combined system immunosuppressive therapy.

Keyword

Systemic vasculitis; rapidly progressive glomerulonephritis

MeSH Terms

Adult
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies/analysis
Cyclophosphamide/therapeutic use
Drug Therapy, Combination
Female
Glomerulonephritis/*complications/immunology/pathology/therapy
Humans
Kidney/ultrastructure
Prednisolone/therapeutic use
Renal Dialysis
Vasculitis/*complications
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Cyclophosphamide
Prednisolone