Korean J Dermatol.  2019 Mar;57(3):149-151.

A Case of Lenalidomide-induced Drug Eruption Presenting as Pruritus and Erythema Covering the Whole Body

• Shin JY
• Hong KR
• Kim JE
• Lee SH
• Park YL

Abstract

Lenalidomide is an immunomodulatory drug used for the treatment of multiple myeloma. Several cases of hematological, gastrointestinal, and cutaneous side effects have been reported for this drug. A 67-year-old patient with multiple myeloma had initially been treated with bortezomib, but the treatment was discontinued due to neurological side effects. The chemotherapeutic regimen of this patient was changed to lenalidomide. Ten days later, erythema and pruritus developed on the entire body. The lenalidomide dose was subsequently reduced and the patient was additionally treated with topical steroids. Because lenalidomide is supplied by the Korean Orphan Drug Center, physicians have limited experience with the drug, and hence, its side effects tend to be underestimated. In addition, the Korean literature lacks reports on such cases. We describe herein a case of lenalidomide-induced drug eruption presenting as a pruritic rash covering the whole body.

Keyword

Drug eruption; Erythema; Pruritus

MeSH Terms

Aged
Bortezomib
Drug Eruptions*
Erythema*
Exanthema
Humans
Multiple Myeloma
Orphan Drug Production
Pruritus*
Steroids
Bortezomib
Steroids