Int Neurourol J.  2019 Mar;23(1):30-39. 10.5213/inj.1836176.088.

A Korean Postmarketing Study Assessing the Effectiveness of OnabotulinumtoxinA for the Treatment of Neurogenic Detrusor Overactivity or Idiopathic Overactive Bladder Using a Validated Patient-Reported Outcome Measure

• Ko KJ
• Jenkins B
• Patel A
• Lee KS

• KMID: 2446744
• DOI: http://doi.org/10.5213/inj.1836176.088

Abstract

PURPOSE
OnabotulinumtoxinA has demonstrated efficacy and safety in the treatment of urinary incontinence (UI) associated with neurogenic detrusor overactivity (NDO) and idiopathic overactive bladder (OAB); however, real-world evidence is limited. This postmarketing surveillance study aimed to assess the effectiveness and safety of onabotulinumtoxinA in Korean patients with UI associated with NDO or OAB with an inadequate response or intolerance to anticholinergics.
METHODS
Patients received 200 U (NDO) or 100 U (OAB) of onabotulinumtoxinA. Effectiveness (assessed using the validated International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]) and safety were assessed for 1-4 months after onabotulinumtoxinA administration.
RESULTS
Overall, 686 patients (NDO, 161; OAB, 525) comprised the safety population; of these, 612 patients were analyzed for effectiveness. There was a significant decrease (P<0.0001) in the mean (standard deviation) ICIQ-SF scores in the NDO (-6.8±5.5) and OAB (-6.0±6.4) groups after onabotulinumtoxinA administration. A decrease of >5 points from baseline in the ICIQ-SF score was observed in 64.9% and 47.3% of patients in the NDO and OAB groups, respectively. Following treatment, 59.9% in the NDO group and 43.0% in the OAB group were dry. There was no effect of age on effectiveness in either group. Only 10 adverse drug reactions (ADRs) were reported in 5.6% of NDO patients and 20 ADRs in 3.2% of OAB patients. Most ADRs in both groups were related to the lower urinary tract such as dysuria (NDO, 1.2%; OAB, 0.6%) and urinary retention (NDO, 0.6%; OAB, 1.5%).
CONCLUSIONS
Effectiveness and safety of onabotulinumtoxinA in Korea in a real-world setting was demonstrated.

Keyword

OnabotulinumtoxinA; Urinary incontinence; Neurogenic urinary bladder; Overactive urinary bladder

MeSH Terms

Cholinergic Antagonists
Drug-Related Side Effects and Adverse Reactions
Dysuria
Humans
Korea
Outcome Assessment (Health Care)*
Urinary Bladder, Neurogenic
Urinary Bladder, Overactive*
Urinary Incontinence
Urinary Retention
Urinary Tract
Cholinergic Antagonists