Int Neurourol J.  2012 Sep;16(3):139-143.

Botulinum Toxin in Neurogenic Detrusor Overactivity

• D'Ancona C
• Ferreira R
• Rassi MC

Abstract

PURPOSE
To evaluate the effects of botulinum toxin on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity.
METHODS
Thirty four adult patients with spinal cord injury and detrusor overactivity were selected. The patients received 300 units of botulinum toxin type A. The endpoints evaluated with the episodes of urinary incontinence and measured the maximum cystometric capacity, maximum amplitude of detrusor pressure and bladder compliance at the beginning and end of the study (24 weeks) and evaluated the quality of life by applying the Qualiveen questionnaire.
RESULTS
A significant decrease in the episodes of urinary incontinence was observed. All urodynamic parameters presented a significant improvement. The same was observed in the quality of life index and the specific impact of urinary problems scores from the Qualiveen questionnaire. Six patients did not complete the study, two due to incomplete follow-up, and four violated protocol and were excluded from the analyses. No systemic adverse events of botulinum toxin type A were reported.
CONCLUSIONS
A botulinum toxin type A showed a significantly improved response in urodynamics parameters and specific and general quality of life.

Keyword

Overactive urinary bladder; Botulinum toxins; Quality of life; Urodynamics

MeSH Terms

Adult
Botulinum Toxins
Botulinum Toxins, Type A
Compliance
Follow-Up Studies
Humans
Quality of Life
Spinal Cord Injuries
Urinary Bladder
Urinary Bladder, Overactive
Urinary Incontinence
Urodynamics
Botulinum Toxins
Botulinum Toxins, Type A