Dement Neurocogn Disord.  2014 Dec;13(4):112-116. 10.12779/dnd.2014.13.4.112.

Topographical Distribution of Lacunes and Cerebral Microbleeds in CADASIL Affected by Hypertension

• Lee JS
• Oh JH
• Song SK
• Choi JC
• Kang SY
• Kang JH

• KMID: 2443075
• DOI: http://doi.org/10.12779/dnd.2014.13.4.112

Abstract

BACKGROUND
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by mutations in the Notch3 gene. Lacunes may reflect occlusive type microangiopathy. However, cerebral microbleeds (CMBs) may reflect bleeding-prone microangiopathy. In the present study, we aimed to determine whether hypertension influence the distribution and severity of lacunes and CMBs in patients with CADASIL.
METHODS
The study population comprised 85 patients who underwent brain MRI, including T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery (FLAIR) image. The patients were divided into two groups depending on the presence or absence of hypertension. In the first, demographic factors, and MRI findings were compared between CADASIL patients with and without hypertension. In the second, we undertook a region by region comparison of number of patients with lacunes or CMBs.
RESULTS
The hypertensive group showed a higher incidence of CMBs in lobar area (p<0.001) and basal ganglia (p=0.014). CMBs tend to be observed more frequently in the thalamus (p=0.058), brainstem (p=0.057), and cerebellum (p=0.052) in the hypertensive group. However, hypertensive group demonstrated a higher incidence of lacunes just in lobar area (p=0.040).
CONCLUSIONS
Our findings suggest that CMBs may be a more sensitive neuroimaging marker of hypertensive arteriopathy in patients with CADASIL.

Keyword

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); Hypertension; Lacunes; Cerebral microbleeds (CMBs)

MeSH Terms

Basal Ganglia
Brain
Brain Stem
CADASIL*
Cerebellum
Demography
Humans
Hypertension*
Incidence
Leukoencephalopathies
Magnetic Resonance Imaging
Neuroimaging
Thalamus

Figure

• 

  Fig. 1 A 63 year-old man who had one stroke (mild left-sided weakness). Susceptibility Weighted Image (SWI) showing multiple CMBs in brain (A, B). 3D-T1 weighted image and Fluid-attenuated inversion recovery (FLAIR) image showing multiple lacunes in brain (C, D). Arrowhead indicates cerebral microbleeds. Arrow points to lacunes.

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