J Korean Med Sci.  2019 Apr;34(13):e107. 10.3346/jkms.2019.34.e107.

Chordomas: Histopathological Study in View of Anatomical Location

• Cha YJ
• Suh YL

• KMID: 2442640
• DOI: http://doi.org/10.3346/jkms.2019.34.e107

Abstract

BACKGROUND
Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base chordoma (SBC) and sacral/spinal chordoma (SC) are unclear as previous studies have been focused on patient prognosis and treatment outcome. This study aimed to evaluate the clinicopathologic features and prognosis of chordoma according to its location.
METHODS
Patients with chordomas were enrolled, and the histopathologic features were compared according to the tumor location.
RESULTS
A total of 52 patients were enrolled. SBCs had more abundant chondroid matrix and diffuse growth pattern, while SCs had non-chondroid, myxoid matrix and a lobulating pattern, typical of chordoma. Old age and residual tumors were risk factors for shorter overall survival in SBCs. The chondroid matrix was an independent risk factor for shorter disease-free survival in the overall population.
CONCLUSION
Chordomas have different histopathologic features depending on the anatomical location.

Keyword

Chordoma; Notochord; Skull Base Neoplasms; Brain Neoplasms; Soft Tissue Neoplasms; Bone Neoplasms

MeSH Terms

Bone Neoplasms
Brain Neoplasms
Chordoma*
Disease-Free Survival
Humans
Neoplasm, Residual
Notochord
Prognosis
Risk Factors
Skeleton
Skull Base
Skull Base Neoplasms
Soft Tissue Neoplasms
Treatment Outcome