J Korean Diabetes.  2018 Dec;19(4):200-207. 10.4093/jkd.2018.19.4.200.

Management of Type 2 Diabetes Mellitus in the Elderly

Affiliations
  • 1Department of Endocrinology and Metabolism, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. imdrksk@chollian.net

Abstract

In Korea, by 2060, the proportion of the elderly population will be 40.1%, and at least one in three persons will have diabetes. Elderly patients with diabetes mellitus have higher rates of premature death, functional disability, and coexisting illnesses such as atherosclerotic cardiovascular disease than those without diabetes. In addition, the risk of geriatric syndrome, such as depression, cognitive dysfunction, urinary incontinence, falls, pain, and polypharmacy, is much higher in those with diabetes. The functional status of each elderly person varies greatly, such that comprehensive geriatric assessments for medical, psychological, functional, and social domains are needed. The goals and methods of diabetes management should be individualized according to the results of these assessments. In the treatment of vulnerable elderly patients with diabetes, hypoglycemia or overtreatment should be avoided.

Keyword

Diabetes mellitus; Elderly; Geriatric assessment

MeSH Terms

Accidental Falls
Aged*
Cardiovascular Diseases
Depression
Diabetes Mellitus
Diabetes Mellitus, Type 2*
Geriatric Assessment
Humans
Hypoglycemia
Korea
Medical Overuse
Mortality, Premature
Polypharmacy
Urinary Incontinence

Figure

  • Fig. 1 Relationship between diabetes-related risk factors and geriatric syndrome in older people with diabetes. *Chronic kidney disease, congestive heart failure, cardiovascular disease, stroke, etc.

  • Fig. 2 Functional categories of older people with diabetes and the focuse of treatment.


Reference

1. Statistics Korea. 2018 Statics on the aged. updated 2018 Sep 27. Available from: http://kostat.go.kr/portal/korea/kor_nw/2/1/index.board?bmode=read&aSeq=370779.
2. Korea Diabetes Association. Diabetes fact sheet in Korea 2018. Seoul: Korea Diabetes Association;2018. p. 40.
3. Motta M, Bennati E, Ferlito L, Passamonte M, Malaguarnera M. Value and significance of new diagnostic criteria of diabetes mellitus in older people. Arch Gerontol Geriatr. 2007; 45:103–108.
Article
4. Araki A, Ito H. Diabetes mellitus and geriatric syndromes. Geriatr Gerontol Int. 2009; 9:105–114.
Article
5. American Diabetes Association. 11. Older adults: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018; 41:Suppl 1. S119–S125.
6. Valencia WM, Florez H. Pharmacological treatment of diabetes in older people. Diabetes Obes Metab. 2014; 16:1192–1203.
Article
7. International Diabetes Federation. Managing older people with type 2 diabetes-global guideline. Brussels: International Diabetes Federation;2013. p. 96.
8. Action to, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; 358:2545–2559.
Article
9. American Diabetes Association. 6. Glycemic targets: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018; 41:Suppl 1. S55–S64.
10. American Geriatrics Society Expert Panel on Care of Older Adults with Diabetes Mellitus. Moreno G, Mangione CM, Kimbro L, Vaisberg E. Guidelines abstracted from the American Geriatrics Society Guidelines for improving the care of older adults with diabetes mellitus: 2013 update. J Am Geriatr Soc. 2013; 61:2020–2026.
Article
11. Sinclair AJ, Paolisso G, Castro M, Bourdel-Marchasson I, Gadsby R, Rodriguez Mañas L. European Diabetes Working Party for Older People. European Diabetes Working Party for Older People 2011 clinical guidelines for type 2 diabetes mellitus. Executive summary. Diabetes Metab. 2011; 37:Suppl 3. S27–S38.
Article
12. Lipska KJ, Bailey CJ, Inzucchi SE. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care. 2011; 34:1431–1437.
Article
13. Lee CG, Boyko EJ, Barrett-Connor E, Miljkovic I, Hoffman AR, Everson-Rose SA, Lewis CE, Cawthon PM, Strotmeyer ES, Orwoll ES. Osteoporotic Fractures in Men (MrOS) Study Research Group. Insulin sensitizers may attenuate lean mass loss in older men with diabetes. Diabetes Care. 2011; 34:2381–2386.
Article
14. Mazokopakis EE, Starakis IK. Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. Diabetes Res Clin Pract. 2012; 97:359–367.
Article
15. Monami M, Cremasco F, Lamanna C, Marchionni N, Mannucci E. Predictors of response to dipeptidyl peptidase-4 inhibitors: evidence from randomized clinical trials. Diabetes Metab Res Rev. 2011; 27:362–372.
Article
16. Imprialos K, Faselis C, Boutari C, Stavropoulos K, Athyros V, Karagiannis A, Doumas M. SGLT-2 inhibitors and cardiovascular risk in diabetes mellitus: a comprehensive and critical review of the literature. Curr Pharm Des. 2017; 23:1510–1521.
Article
17. Sinclair AJ, Bode B, Harris S, Vijapurkar U, Shaw W, Desai M, Meininger G. Efficacy and safety of canagliflozin in individuals aged 75 and older with type 2 diabetes mellitus: a pooled analysis. J Am Geriatr Soc. 2016; 64:543–552.
Article
18. Bethel MA, Patel RA, Merrill P, Lokhnygina Y, Buse JB, Mentz RJ, Pagidipati NJ, Chan JC, Gustavson SM, Iqbal N, Maggioni AP, Öhman P, Poulter NR, Ramachandran A, Zinman B, Hernandez AF, Holman RR. EXSCEL Study Group. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol. 2018; 6:105–113.
Article
19. Boustani MA, Pittman I 4th, Yu M, Thieu VT, Varnado OJ, Juneja R. Similar efficacy and safety of once-weekly dulaglutide in patients with type 2 diabetes aged ≥ 65 and < 65 years. Diabetes Obes Metab. 2016; 18:820–828.
Article
Full Text Links
  • JKD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr