Korean J Dermatol.  2019 Feb;57(2):84-88.

A Case of Primary Cutaneous Follicle Center Lymphoma (PCFCL) Misdiagnosed as Phymatous Rosacea

Affiliations
  • 1Department of Dermatology, School of Medicine, Keimyung University, Daegu, Korea. ryoo111@dsmc.or.kr

Abstract

PCFCL is a subtype of primary cutaneous B-cell lymphoma (PCBCL), which is defined as a neoplasm of the centrocytes and centroblasts with or without the formation of follicles. It is rare in Asians and shows considerable variability in terms of clinical presentation and histological features, which makes it difficult to diagnose. A 77-year-old man visited our clinic with a 2-month history of erythematous telangiectatic patches and plaques on the face. Under the suspicion of phymatous rosacea, he received two pulsed dye-laser treatments at a local medical center and four pulsed dye-laser treatments at our outpatient clinic, but showed no improvement. Skin biopsy and immunohistochemical findings were compatible with PCFCL. Computed tomography (CT), positron emission tomography-computed tomography (PET-CT) and bone marrow biopsy revealed no evidence of extracutaneous involvement. Skin lesions improved after four cycles of chemotherapy with cyclophosphamide, vincristine, and prednisolone. Herein, we report an educational case of PCFCL misdiagnosed as phymatous rosacea.

Keyword

Phymatous rosacea; Primary cutaneous B-cell lymphoma; Primary cutaneous follicle center lymphoma

MeSH Terms

Aged
Ambulatory Care Facilities
Asian Continental Ancestry Group
Biopsy
Bone Marrow
Cyclophosphamide
Drug Therapy
Electrons
Humans
Lymphoma*
Lymphoma, B-Cell
Prednisolone
Rosacea*
Skin
Vincristine
Cyclophosphamide
Prednisolone
Vincristine
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