Korean J Pediatr Infect Dis.  1997 May;4(1):140-149. 10.14776/kjpid.1997.4.1.140.

The Study of IgG subclasses in Acute stage of Kawasaki Disease

• Kim MS
• Kim YS
• Cho NJ
• Kim KS

• KMID: 2440367
• DOI: http://doi.org/10.14776/kjpid.1997.4.1.140

Abstract

PURPOSE
Kawasaki Disease(KD) is a febrile disease with acute multisystemic vasculitis which is seen commonly in early childhood. The cause and etiologic agents are still unknown to identify using ordinary bacterial and viral culture, but the clinical labaratory studies suggest that KD is one of autoimmune disorder caused by infectious agents, but that is not proved yet. The study was performed to investigate the IgG subclasses in acute stage of KB before treatment of IVIG(Intravenous immunoglobulin). METHOD: The 35 cases in acute stage of KD before treatment of IVIG who were hospitalized from jan. 1995 to dec. 1996. The obtained sera were measured level of total IgG, IgM, IgA, IgE and IgG subclasses IgGl, IgG2, IgG3, IgG4 by using EIA and SRID method.
RESULTS
1) The sex ratio is male to female is 1.5: 1.0, and male is prone to infected. 2) Total IgG, IgM, IgA and IgE level is normal range with age adjusted, but few cases are shown slight high level of total IgG compare to normal range of age adjusted. 3) acute phage reactants such as CRP, C3, ESR are all increased in acute stage of cases. 4) IgG subclasses IgGl, IgG2, IgG3 are shown normal range of age adjusted, but remarkably low level of IgG4 in all of cases.
CONCLUSIONS
The low level of IgG4 is able to increasing the incidence of KD, and may use early diagnostic tools combine with other clinical symptoms and signs. But the resulsts of reported studies are different to each other, so it needs more times and cases to get final evaluation of changes of serum immnunoglobulin levels correlate to increase the incidence of high risk group of KD patients.

Keyword

Kawasaki disease; IgG subclasses

MeSH Terms

Bacteriophages
Female
Humans
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G*
Immunoglobulin M
Immunoglobulins, Intravenous
Incidence
Male
Methods
Mucocutaneous Lymph Node Syndrome*
Reference Values
Sex Ratio
Vasculitis
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins, Intravenous