Korean J Pediatr Infect Dis.  1997 May;4(1):116-125. 10.14776/kjpid.1997.4.1.116.

Studies on the Duration of Immunity and Production of Antibody following Immunization with Inactivated Killed Japanese Encephalitis Vaccine

• Cho HW
• Nam JH
• Lee HC
• Kim JJ
• Kim EJ
• Chae SL
• Lee YS
• Lu JJ

• KMID: 2440364
• DOI: http://doi.org/10.14776/kjpid.1997.4.1.116

Abstract

PRUPOSE: Studies on the duration of immune response against Japanese encephalitis virus from recipients with JE vaccine (Nakayama-NIH strain) in Korea.
METHODS
To determinate the immune response and the duration of antibody against JE vaccine, 213 students were examined since 1994 using hemmaglutination inhibition test and plaque reduction neutralization test (PRNT).
RESULTS
24 months after the first vaccination, haemmaglutination inhibition and neutralizing antibody maintained from the recipients 63.4% (>1:20) and 100% (>1:20), respectively. In April 1996, one dose booster to the same recipients those who were vaccinated in 1994, the GMT antibody for HI and PRNT titer were both increased from 1:11.6 to 1:13.2 and 1:275.7 to 1:348.1, respectively, after 6 months booster (after 30 months from the initial vaccination). This results showed that the antibody from the active immunity could be maintained more than 12 months after the initial vaccination. On the basis of these results, inactivated killed JE vaccine (Nakayama-NIH strain) using for preventing against JE purpose seems to produce antibody enough to protect against JE at present .
CONCLUSIONS
Along with the results of this study demonstrating duration of antibody, the active immunization could be maintained as long as by initial vaccination of 2 doses, a single dose of booster vaccination made during a period of 1 month to 12 months and the successive booster vaccination by 2 or 3 year intervals. However, the immunization schedule should be concerned with both epidemiology of disease and the immune response of vaccinated individuals.

Keyword

Japanese encephalitis virus; Hemagglutination inhibition test; Plaque-reduction neutralization test

MeSH Terms

Antibodies, Neutralizing
Asian Continental Ancestry Group*
Encephalitis Virus, Japanese
Encephalitis, Japanese*
Epidemiology
Hemagglutination Inhibition Tests
Humans
Immunity, Active
Immunization Schedule
Immunization*
Korea
Neutralization Tests
Vaccination
Antibodies, Neutralizing