Exp Mol Med.
2018 Feb;50(2):e436. 10.1038/emm.2017.273.
Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications
- Affiliations
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- 1Department of Physiology, Faculty of Medicine, University of Prishtina, Prishtina, Kosova, Albania. driton.vela@uni-pr.edu
- 2Department of Histology and Pathology, Faculty of Medicine, University of Prishtina, Prishtina, Kosova, Albania.
- KMID: 2440018
- DOI: http://doi.org/10.1038/emm.2017.273
Abstract
- Hepcidin is a crucial peptide for regulating cellular iron efflux. Because iron is essential for cell survival, especially for highly active cells, such as tumor cells, it is imperative to understand how tumor cells manipulate hepcidin expression for their own metabolic needs. Studies suggest that hepcidin expression and regulation in tumor cells show important differences in comparison with those in non-tumorous cells. These differences should be investigated to develop new strategies to fight cancer cells. Manipulating hepcidin expression to starve cancer cells for iron may prove to be a new therapy in the anticancer arsenal.
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