Korean J Obstet Gynecol.
2006 Apr;49(4):840-846.
The Expression of Clusterin in Cervical Cancer tissues
- Affiliations
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- 1Department of Obstetrics and Gynecology, Saint Vincent Hospital, The Catholic University of Korea. dhkim2k@catholic.ac.kr
- 2Research Institute of Medical Science of Saint Vincent Hospital, The Catholic University of Korea.
- 3Department of Obstetrics and Gynecology, Shesmedi Hospital, Korea.
Abstract
OBJECTIVE
Immunohistochemistry was performed on normal and cervical cancer tissues to determine the differential expression patterns of clusterin.
METHODS
Fifteen normal cervical tissues and thirty-two primary cervical cancer tissues were used. Clusterin expression was determined with immunohistochemical staining and quantified with scoring system.
RESULTS
The normal cervical tissues expressed low levels of clusterin expression and their mean score was 1.35. On the contrary cervical cancer tissues showed high levels of clusterin expression with mean score, 4.08. And the difference of expression was statistically significant (P<0.05).
CONCLUSION
These data suggest that clusterin expression is higher in cervical cancer tissues than normal cervical tissues.
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