J Korean Neuropsychiatr Assoc.  2019 Feb;58(1):47-54. 10.4306/jknpa.2019.58.1.47.

Functional Disabilities Evaluated using World Health Organization Disability Assessment Schedule 2.0 in Patients with Chronic Schizophrenia and Its Related Factors

• Park K
• Lee DK
• Lee H
• Kim CE
• Ryu S

• KMID: 2439027
• DOI: http://doi.org/10.4306/jknpa.2019.58.1.47

Abstract

OBJECTIVES
This study examined the functional disabilities of patients with chronic schizophrenia using WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) and its related factors.
METHODS
The subjects consisted of 86 patients with schizophrenia with more than 10 years' duration of illness and 40 healthy volunteers. The functional disabilities and psychopathology were evaluated using the WHODAS 2.0 and 18-items Brief Psychiatric Rating Scale (BPRS-18), respectively. This study analyzed the six sub-domains ('cognition', 'mobility', 'self-care', 'getting along', 'life activities', and 'participation') of WHODAS 2.0 and the four sub-scales ('positive symptoms', 'negative symptoms', 'affect', and 'resistance') of BPRS-18.
RESULTS
Patients with chronic schizophrenia experienced severe functional disabilities across all six sub-domains of WHODAS 2.0 compared to healthy people. Hierarchical regression showed that 'negative symptoms' explained the disabilities in the WHODAS 2.0 sub-domains of 'cognition' (p<0.05), 'self-care' (p<0.05), 'getting along' (p<0.01), and 'life activities' (p<0.05). 'Positive symptoms' and 'affect' explained the disabilities in 'cognition' (p<0.01 and p<0.05, respectively) and 'participation' (p<0.05 and p<0.01, respectively). 'Resistance' was found to be a predictor of 'getting along' disabilities (p<0.01).
CONCLUSION
Negative symptoms mainly accounted for the multiple domains of functional disabilities in the WHODAS 2.0 but residual positive and affective symptoms could also deteriorate the cognition and social participation of patients with chronic schizophrenia.

Keyword

Schizophrenia; Disability evaluation; Psychopathology

MeSH Terms

Affective Symptoms
Appointments and Schedules*
Brief Psychiatric Rating Scale
Cognition
Disability Evaluation
Global Health*
Healthy Volunteers
Humans
Psychopathology
Schizophrenia*
Social Participation
World Health Organization*

Figure

• 

  Fig. 1. Comparisons of WHODAS 2.0 mean scores between normal and patients of schizophrenia. WHODAS 2.0 : World Health Organization Disability Assessment Schedule 2.0, SD : Standard deviation.

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