Epidemiol Health.  2018;40:e2018054. 10.4178/epih.e2018054.

Incidence of varicella in children in Jeju-do, Korea, 2005–2016: age-period-cohort analysis

• Kim J
• Kim JE
• Bae JM

• KMID: 2438504
• DOI: http://doi.org/10.4178/epih.e2018054

Abstract

OBJECTIVES
Although the nationwide inoculation rate of varicella vaccine was approximately 95% in Korean children recently, the number of notified varicella cases is unexpectedly continuously increasing till now. To suggest some hypotheses regarding this discrepancy, an age-period-cohort (APC) analysis as a descriptive epidemiology study was conducted for children residing in Jeju-do, Korea.
METHODS
The raw data were obtained from the nationwide database for insurance claim of healthcare fee provided by the National Health Insurance Service, Korea. The selection criteria were children aged 2-13 years who visited any healthcare center due to varicella from 2005 to 2016 while residing in Jeju-do. After calculating the birth cohort-specific crude incidence rates by age and year, the intrinsic estimator method was used to perform the APC analysis.
RESULTS
As the annual crude incidence rates decreased with increasing age between 2005 and 2016, the age and period effects also decreased. The intrinsic estimator coefficients suggesting the cohort effect shifted from positive to negative in 2011, the starting year of free varicella vaccine program in Jeju-do.
CONCLUSIONS
The results suggested that inoculated varicella vaccines have preventive effects. However, further studies to evaluate waning immunity would be needed.

Keyword

Chickenpox; Chickenpox vaccine; Cohort effect; Immunization programs; Immunization schedule; Measles-mumps-rubella vaccine

MeSH Terms

Chickenpox Vaccine
Chickenpox*
Child*
Cohort Effect
Delivery of Health Care
Epidemiology
Fees and Charges
Humans
Immunization Programs
Immunization Schedule
Incidence*
Insurance
Jeju-do*
Korea*
Measles-Mumps-Rubella Vaccine
Methods
National Health Programs
Parturition
Patient Selection
Vaccines
Chickenpox Vaccine
Measles-Mumps-Rubella Vaccine
Vaccines