Soonchunhyang Med Sci.
2018 Jun;24(1):76-80. 10.0000/sms.2018.24.1.76.
Two Cases of Neonatal Lupus and Literature Review
- Affiliations
-
- 1Department of Pediatrics, Soonchunhyang University College of Medicine, Cheonan, Korea. pjstable@schmc.ac.kr
- 2Department of Dermatology, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 3Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 4Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
- KMID: 2437771
- DOI: http://doi.org/10.0000/sms.2018.24.1.76
Abstract
- Neonatal lupus is a rare rheumatic disease. Clinical manifestations include characteristic annular or macular rashes, congenital heart block, cytopenias, and hepatitis. Neonatal lupus is caused by transmission of maternal immunoglobulin G autoantibodies such as anti-SSA/Ro antibody or anti-SSB/La antibody to the fetus through the placenta. We report two cases of neonatal lupus. The first case refers to an 18-day-old male with annular rashes on both cheeks, neutropenia, positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. His mother was diagnosed with systemic lupus erythematosus characterized by positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. The second case represents a 32-day-old female with annular rash on both hands, soles, and the genital area, neutropenia, hepatitis, positive tests for antinuclear antibody, and anti-SSA/Ro antibody. Skin punch biopsy was conducted. Her mother did not have history of connective tissue diseases. We referred her mother to the division of rheumatology of the department of internal medicine. The mother was suspected with primary Sjögren's syndrome because of arthralgia and dry eye symptoms with positive tests for antinuclear antibody, anti-SSA/Ro antibody, anti-SSB/La antibody, and rheumatoid factor. It is necessary to suspect neonatal lupus in neonates or infants with characteristic annular rash with or without maternal history of connective tissue disorders.
Keyword
MeSH Terms
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Antibodies, Antinuclear
Arthralgia
Autoantibodies
Biopsy
Cheek
Connective Tissue
Connective Tissue Diseases
Exanthema
Female
Fetus
Hand
Heart Block
Hepatitis
Humans
Immunoglobulin G
Infant
Infant, Newborn
Internal Medicine
Lupus Erythematosus, Systemic
Male
Mothers
Neutropenia
Placenta
Rheumatic Diseases
Rheumatoid Factor
Rheumatology
Skin
Antibodies, Antinuclear
Autoantibodies
Immunoglobulin G
Rheumatoid Factor
