Neonatal Med.  2021 Aug;28(3):139-142. 10.5385/nm.2021.28.3.139.

Macrophage Activation Syndrome Presented in a Case of Neonatal Lupus

• Kang CM
• Choi J
• Lee J

• KMID: 2519777
• DOI: http://doi.org/10.5385/nm.2021.28.3.139

Abstract

Macrophage activation syndrome (MAS) is a potentially life-threatening complication in many autoimmune diseases. Early recognition and intervention are essential for a favorable outcome. Neonatal lupus, an acquired autoimmune disease in neonates caused by the transplacental passage of maternal autoantibodies, is rare and usually self-limited. Herein, we report a case of MAS in a patient with neonatal lupus, which improved with intravenous immunoglobulin.

Keyword

Macrophage activation syndrome; Neonatal lupus; Immunoglobulins, intravenous

Figure

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  Figure 1. Changes in clinical course and laboratory findings in our case. Abbreviations: BT, body temperature; pRBC, packed red blood cells; IVIG, intravenous immunoglobulin; G-CSF, granulocyte-colony stimulating factor; Hb, hemoglobin; ANC, Absolute neutrophil count; CRP, C-reactive protein; AST, aspartate transaminase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; TG, triglyceride.

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