Soonchunhyang Med Sci.  2018 Jun;24(1):15-21. 10.0000/sms.2018.24.1.15.

Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention

• Park BW
• Kwon SS
• Lee MH
• Kim DH
• Hyon MS
• Bang DW

• KMID: 2437761
• DOI: http://doi.org/10.0000/sms.2018.24.1.15

Abstract

OBJECTIVE
Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI).
METHODS
In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline.
RESULTS
CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis.
CONCLUSION
In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.

Keyword

Nephropathy; Percutaneous coronary intervention; Contrast media

MeSH Terms

Catheterization
Catheters
Contrast Media
Creatinine
Cystatin C
Humans
Interleukin-18
Kidney
Neutrophils
Percutaneous Coronary Intervention*
Contrast Media
Creatinine
Cystatin C
Interleukin-18